健康与疾病状态下的肺实质力学
Lung parenchymal mechanics in health and disease.
作者信息
Faffe Débora S, Zin Walter A
机构信息
Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
出版信息
Physiol Rev. 2009 Jul;89(3):759-75. doi: 10.1152/physrev.00019.2007.
The mechanical properties of lung tissue are important determinants of lung physiological functions. The connective tissue is composed mainly of cells and extracellular matrix, where collagen and elastic fibers are the main determinants of lung tissue mechanical properties. These fibers have essentially different elastic properties, form a continuous network along the lungs, and are responsible for passive expiration. In the last decade, many studies analyzed the relationship between tissue composition, microstructure, and macrophysiology, showing that the lung physiological behavior reflects both the mechanical properties of tissue individual components and its complex structural organization. Different lung pathologies such as acute respiratory distress syndrome, fibrosis, inflammation, and emphysema can affect the extracellular matrix. This review focuses on the mechanical properties of lung tissue and how the stress-bearing elements of lung parenchyma can influence its behavior.
肺组织的力学特性是肺生理功能的重要决定因素。结缔组织主要由细胞和细胞外基质组成，其中胶原蛋白和弹性纤维是肺组织力学特性的主要决定因素。这些纤维具有本质上不同的弹性特性，沿着肺部形成一个连续的网络，并负责被动呼气。在过去十年中，许多研究分析了组织组成、微观结构和宏观生理学之间的关系，表明肺的生理行为既反映了组织单个成分的力学特性，也反映了其复杂的结构组织。不同的肺部疾病，如急性呼吸窘迫综合征、纤维化、炎症和肺气肿，会影响细胞外基质。本综述重点关注肺组织的力学特性，以及肺实质的应力承受元件如何影响其行为。
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