肥大细胞羧肽酶A生物学功能的新见解。

Novel insights into the biological function of mast cell carboxypeptidase A.

作者信息

Pejler Gunnar, Knight Stefan D, Henningsson Frida, Wernersson Sara

机构信息

Swedish University of Agricultural Sciences, Dept of Anatomy, Physiology and Biochemistry, Uppsala 75123, Sweden.

出版信息

Trends Immunol. 2009 Aug;30(8):401-8. doi: 10.1016/j.it.2009.04.008. Epub 2009 Jul 28.

DOI:10.1016/j.it.2009.04.008

PMID:19643669

Abstract

When mast cells are activated they can respond by releasing their secretory granule compounds, including mast cell-specific proteases of chymase, tryptase and carboxypeptidase A (MC-CPA) type. MC-CPA is a dominant protein component of the mast cell granule and the MC-CPA gene is extremely highly expressed. Despite this, relatively little has been known of its biological function. However, the recent generation of mouse strains lacking MC-CPA has opened up new possibilities for investigations related to this protease. This recent development has revealed a role for MC-CPA in regulating innate immunity responses, including the degradation of harmful substances such as the vasoconstrictive factor endothelin 1 and snake venom toxins. Here, we summarize the current knowledge of MC-CPA.

摘要

肥大细胞被激活后，可通过释放其分泌颗粒化合物做出反应，这些化合物包括肥大细胞特异性蛋白酶，如糜蛋白酶、组织蛋白酶G和羧肽酶A（MC-CPA）类型。MC-CPA是肥大细胞颗粒的主要蛋白质成分，且MC-CPA基因表达极高。尽管如此，人们对其生物学功能的了解相对较少。然而，最近培育出的缺乏MC-CPA的小鼠品系为与这种蛋白酶相关的研究开辟了新的可能性。这一最新进展揭示了MC-CPA在调节固有免疫反应中的作用，包括降解诸如血管收缩因子内皮素1和蛇毒毒素等有害物质。在此，我们总结了目前关于MC-CPA的知识。