针对肥胖症中的微小RNA
Targeting microRNAs in obesity.
作者信息
Xie Huangming, Sun Lei, Lodish Harvey F
机构信息
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA.
出版信息
Expert Opin Ther Targets. 2009 Oct;13(10):1227-38. doi: 10.1517/14728220903190707.
Obesity is a serious health problem worldwide associated with an increased risk of life-threatening diseases such as type 2 diabetes, atherosclerosis, and certain types of cancer. Fundamental for the development of novel therapeutics for obesity and its associated metabolic syndromes is an understanding of the regulation of fat cell development. Recent computational and experimental studies have shown that microRNAs (miRNAs) play a role in metabolic tissue development, lipid metabolism and glucose homeostasis. In addition, many miRNAs are dysregulated in metabolic tissues from obese animals and humans, which potentially contributes to the pathogenesis of obesity-associated complications. In this review we summarize the current state of understanding of the roles of miRNAs in metabolic tissues under normal development and obese conditions, and discuss the potential use of miRNAs as therapeutic targets.
肥胖是一个全球性的严重健康问题，与患2型糖尿病、动脉粥样硬化和某些类型癌症等危及生命疾病的风险增加相关。了解脂肪细胞发育的调控是开发肥胖及其相关代谢综合征新型疗法的基础。最近的计算和实验研究表明，微小RNA（miRNA）在代谢组织发育、脂质代谢和葡萄糖稳态中发挥作用。此外，许多miRNA在肥胖动物和人类的代谢组织中表达失调，这可能导致肥胖相关并发症的发病机制。在本综述中，我们总结了目前对miRNA在正常发育和肥胖条件下代谢组织中作用的理解现状，并讨论了将miRNA用作治疗靶点的潜在用途。
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