通过壳聚糖和聚乙二醇二丙烯酸酯（PEGDA）的迈克尔加成反应制备的光聚合壳聚糖衍生物。
Photo-polymeriable chitosan derivative prepared by Michael reaction of chitosan and polyethylene glycol diacrylate (PEGDA).
机构信息
State Key Laboratory of Chemical Resource Engineering, College of Materials Science and Engineering, Beijing University of Chemical Technology, 15 Beisanhuan East Road, Chaoyang, Beijing 100029, PR China.
出版信息
Int J Biol Macromol. 2009 Dec 1;45(5):499-503. doi: 10.1016/j.ijbiomac.2009.08.007. Epub 2009 Aug 29.
N-Alkyled photo-polymeriable chitosan derivative (PEGDA-CS) was synthesized by Michael reaction of chitosan and polyethylene glycol diacrylate (PEGDA) under mild reaction conditions. The chemical structure and physical properties of PEGDA-CS were characterized by FT-IR, (1)H NMR, XRD and TG techniques. The degree of substitution (DS) of PEGDA-CS could be calculated from (1)H NMR. PEGDA-CS exhibited good solubility in distilled water. XRD analysis showed that PEGDA-CS was amorphous. TG results demonstrated that thermal stability of the derivate was lower than that of chitosan. Antimicrobial test showed that PEGDA-CS had the antimicrobial activity on Escherichia coli. It could photopolymerize under ultraviolet light with 2959 as initiator.
N-烷基化光聚合壳聚糖衍生物（PEGDA-CS）通过壳聚糖和聚乙二醇二丙烯酸酯（PEGDA）在温和的反应条件下的迈克尔加成反应合成。PEGDA-CS 的化学结构和物理性质通过傅里叶变换红外光谱（FT-IR）、（1）H 核磁共振（NMR）、X 射线衍射（XRD）和热重分析（TG）技术进行了表征。可以通过（1）H NMR 计算 PEGDA-CS 的取代度（DS）。PEGDA-CS 在蒸馏水中具有良好的溶解性。XRD 分析表明 PEGDA-CS 为无定形。TG 结果表明，该衍生物的热稳定性低于壳聚糖。抗菌试验表明，PEGDA-CS 对大肠杆菌具有抗菌活性。以 2959 作为引发剂，它可以在紫外光下光聚合。
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