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初次腰椎间盘切除术后短间隔计算机断层扫描和磁共振成像的前瞻性队列研究:与复发性椎间盘突出和椎间盘高度丢失相关的因素

A prospective cohort study of close interval computed tomography and magnetic resonance imaging after primary lumbar discectomy: factors associated with recurrent disc herniation and disc height loss.

作者信息

McGirt Matthew J, Eustacchio Sandro, Varga Peter, Vilendecic Milorad, Trummer Martin, Gorensek Miro, Ledic Darko, Carragee Eugene J

机构信息

Department of Neurosurgery, The Johns Hopkins Hospital, Baltimore, MD 21287, USA.

出版信息

Spine (Phila Pa 1976). 2009 Sep 1;34(19):2044-51. doi: 10.1097/BRS.0b013e3181b34a9a.

Abstract

STUDY DESIGN

Prospective cohort study.

OBJECTIVE

We performed a prospective cohort study with standardized postoperative lumbar imaging every 3 months for a year then annually to assess the incidence and factors associated with same-level recurrent disc herniation.

SUMMARY OF BACKGROUND DATA

The true incidence of same-level recurrent disc herniation after lumbar discectomy is unclear. Retrospective studies have reported widely varying incidences between 3% and 18%. Prospective controlled studies are lacking.

METHODS

A total of 108 patients undergoing first-time lumbar discectomy for refractory radiculopathy were enrolled. Baseline lumbar CT and MRI and standardized clinical data were assessed before surgery, and CT and MRI scans repeated 6 weeks, 3, 6, 9, 12, and 24-months after surgery and at the time of recurrent sciatica. Age, weight, preoperative disc volume, and height, volume of disc removed, and size of anular defect were compared with postoperative disc height loss and recurrent disc herniation using regression analysis.

RESULTS

One hundred patients (41 +/- 10 years old) were available for 1-year (93%) and 76 (70%) for 2-year follow-up (mean follow-up: 25 +/- 12 months). Improvement in all outcome measures was observed by 6 weeks after surgery (P < 0.005). An 18% loss of disc height was observed 3 months after surgery, progressing to 26% by 2 years. Eleven (10.2%) patients experienced recurrent disc herniation requiring revision discectomy a mean 10.5 months after surgery. Subjects with larger anular defects (P = 0.019) and with smaller percentage of disc volume removed (P = 0.028) were associated with an increased risk of recurrent disc herniation. Conversely, those from whom greater disc volumes were removed (P = 0.024) had more progressive disc height loss by 6 months after surgery.

CONCLUSION

Larger anular defects and less disc removal increased the risk of reherniation. Greater volumes of disc removal were associated with accelerated disc height loss. In the setting of larger anular defects or less aggressive disc removal, concern for recurrent herniation should be increased during outpatient follow-up. In this situation effective anular repair may be helpful.

摘要

研究设计

前瞻性队列研究。

目的

我们进行了一项前瞻性队列研究,术后每3个月进行一次标准化腰椎成像,持续一年,之后每年进行一次,以评估同节段复发性椎间盘突出症的发生率及相关因素。

背景数据总结

腰椎间盘切除术后同节段复发性椎间盘突出症的真实发生率尚不清楚。回顾性研究报告的发生率差异很大,在3%至18%之间。缺乏前瞻性对照研究。

方法

共纳入108例因难治性神经根病首次接受腰椎间盘切除术的患者。术前评估基线腰椎CT和MRI以及标准化临床数据,术后6周、3、6、9、12和24个月以及复发性坐骨神经痛时重复进行CT和MRI扫描。使用回归分析比较年龄、体重、术前椎间盘体积和高度、切除的椎间盘体积以及纤维环缺损大小与术后椎间盘高度丢失和复发性椎间盘突出症的关系。

结果

100例患者(41±10岁)完成了1年随访(93%),76例(70%)完成了2年随访(平均随访:25±12个月)。术后6周时所有结局指标均有改善(P<0.005)。术后3个月观察到椎间盘高度丢失18%,到2年时进展至26%。11例(10.2%)患者经历了复发性椎间盘突出症,平均在术后10.5个月需要再次进行椎间盘切除术。纤维环缺损较大(P=0.019)且切除的椎间盘体积百分比较小(P=0.028)的患者复发性椎间盘突出症风险增加。相反,术后6个月时,切除椎间盘体积较大的患者(P=0.024)椎间盘高度丢失更明显。

结论

较大的纤维环缺损和较少的椎间盘切除增加了再突出的风险。较多的椎间盘切除与椎间盘高度加速丢失有关。在纤维环缺损较大或椎间盘切除不太积极的情况下,门诊随访期间应增加对复发性突出的关注。在这种情况下,有效的纤维环修复可能会有帮助。

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