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“MIATA”——关于T细胞检测的最低限度信息

"MIATA"-minimal information about T cell assays.

作者信息

Janetzki Sylvia, Britten Cedrik M, Kalos Michael, Levitsky Hyam I, Maecker Holden T, Melief Cornelius J M, Old Lloyd J, Romero Pedro, Hoos Axel, Davis Mark M

出版信息

Immunity. 2009 Oct 16;31(4):527-8. doi: 10.1016/j.immuni.2009.09.007.

Abstract

Immunotherapy, especially therapeutic vaccination, has a great deal of potential in the treatment of cancer and certain infectious diseases such as HIV (Allison et al., 2006; Fauci et al., 2008; Feldmann and Steinman, 2005). Numerous vaccine candidates have been tested in patients with a variety of tumor types and chronic viral diseases. Often, the best way to assess the clinical potential of these vaccines is to monitor the induced T cell response, and yet there are currently no standards for reporting these results. This letter is an effort to address this problem.

摘要

免疫疗法,尤其是治疗性疫苗接种,在癌症及某些传染病(如HIV)的治疗中具有巨大潜力(Allison等人,2006年;Fauci等人,2008年;Feldmann和Steinman,2005年)。众多候选疫苗已在患有各种肿瘤类型和慢性病毒性疾病的患者中进行了测试。通常,评估这些疫苗临床潜力的最佳方法是监测诱导的T细胞反应,然而目前尚无报告这些结果的标准。本信函旨在解决这一问题。

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