美国国立卫生研究院-美国退休人员协会饮食与健康研究中的酒精摄入量与甲状腺癌风险
Alcohol intake and risk of thyroid cancer in the NIH-AARP Diet and Health Study.
作者信息
Meinhold C L, Park Y, Stolzenberg-Solomon R Z, Hollenbeck A R, Schatzkin A, Berrington de Gonzalez A
机构信息
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120Executive Boulevard, Rockville, MD 20852, USA.
出版信息
Br J Cancer. 2009 Nov 3;101(9):1630-4. doi: 10.1038/sj.bjc.6605337. Epub 2009 Sep 29.
BACKGROUND
Certain studies suggest that alcohol may reduce the risk of thyroid cancer in women, but the effect in men remains unclear.
METHODS
We analysed the association between alcohol and thyroid cancer in a large (n=490 159) prospective NIH-AARP Diet and Health Study with self-reported beer, wine, and liquor intakes.
RESULTS
Over 7.5 years of follow-up (median), 170 men and 200 women developed thyroid cancer. Overall, the thyroid cancer risk decreased with greater alcohol consumption (> or =2 drinks per day vs none, relative risk=0.57, 95% CI 0.36-0.89, P-trend=0.01).
CONCLUSIONS
These results suggest a potential protective role for alcohol consumption in thyroid cancer.
背景
某些研究表明，酒精可能降低女性患甲状腺癌的风险，但对男性的影响仍不明确。
方法
我们在一项大型（n = 490159）前瞻性国立卫生研究院-美国退休人员协会饮食与健康研究中，分析了酒精与甲状腺癌之间的关联，该研究采用自我报告的啤酒、葡萄酒和烈酒摄入量。
结果
在超过7.5年的随访（中位数）中，170名男性和200名女性患了甲状腺癌。总体而言，甲状腺癌风险随着酒精摄入量的增加而降低（每天饮用≥2杯酒与不饮酒相比，相对风险=0.57，95%可信区间0.36 - 0.89，P趋势=0.01）。
结论
这些结果表明酒精消费在甲状腺癌中可能具有潜在的保护作用。
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