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帕金森病患者的震颤抑制矫形器:频率范围视角

Tremor suppression orthoses for parkinson's patients: a frequency range perspective.

作者信息

Rahimi Fariborz, Almeida Quincy J, Wang David, Janabi-Sharifi Farrokh

机构信息

Department of Electrical Engineering, University of Waterloo, Waterloo, ON, Canada.

出版信息

Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:1565-8. doi: 10.1109/IEMBS.2009.5332392.

Abstract

While the majority of tremor-afflicted Parkinso-nian (PD) patients suffer from rest tremors, which is not considered highly disabling, a portion of these PD patients also demonstrate action tremors that interfere with their daily lives. Two main considerations in designing an orthosis that aims at suppressing the tremor, are the frequency bands of the tremor and the joints tremor affects. Nine subjects, which included six healthy people, two PD patients with typical tremor afflictions, and a PD patient with severe tremor of not only in her fingers and wrist, but also in her elbow, participated in this study. The highly afflicted patient displayed the need for tremor suppression in action as well as when in rest. The study focuses on uncommon elbow tremors and demonstrates that, for typically afflicted patients, tremor amplitudes are comparable to healthy subjects, but the frequency distribution of the tremors are different at high levels of elbow torque. For the highly afflicted patient, both tremor amplitude and its frequency distribution are different at all levels of elbow torque. The study further investigates the tremors in two bands of frequency on both hands of the highly troubled patient before, and after medication. The two bands are those of classical Parkinsonian tremor (4-6 Hz) and physiological (or enhanced physiological) tremor (8-12 Hz). Power spectrum and tremor amplitude comparisons reveal that, for part of tremulous PD patients, both tremors coexist and, depending on the level of affliction, the designed orthosis needs to suppress tremors in both bands, even at more proximal joints, such as the elbow.

摘要

虽然大多数患有震颤的帕金森病(PD)患者患有静止性震颤,这种震颤被认为不会造成严重残疾,但这些PD患者中的一部分也表现出动作性震颤,这会干扰他们的日常生活。设计旨在抑制震颤的矫形器时,两个主要考虑因素是震颤的频段以及震颤所影响的关节。九名受试者参与了这项研究,其中包括六名健康人、两名患有典型震颤症状的PD患者以及一名不仅手指和手腕严重震颤,肘部也严重震颤的PD患者。病情严重的患者在活动时以及休息时都表现出对震颤抑制的需求。该研究聚焦于不常见的肘部震颤,并表明,对于典型患病患者,在高肘部扭矩水平下,震颤幅度与健康受试者相当,但震颤的频率分布不同。对于病情严重的患者,在所有肘部扭矩水平下,震颤幅度及其频率分布均不同。该研究进一步调查了病情严重患者在用药前后双手两个频率频段的震颤情况。这两个频段分别是典型帕金森震颤频段(4 - 6Hz)和生理性(或增强生理性)震颤频段(8 - 12Hz)。功率谱和震颤幅度比较显示,对于部分震颤型PD患者,两种震颤同时存在,并且根据患病程度,设计的矫形器需要抑制两个频段的震颤,甚至在更靠近身体近端的关节,如肘部。

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