线粒体复合物 V 的扰动改变了果蝇对饮食限制的反应。
Perturbation of mitochondrial complex V alters the response to dietary restriction in Drosophila.
机构信息
Department of Physiological Science, University of California, Los Angeles, CA 90095-1527, USA.
出版信息
Aging Cell. 2010 Feb;9(1):100-3. doi: 10.1111/j.1474-9726.2009.00537.x. Epub 2009 Nov 25.
Abstract
Studies in a broad spectrum of model organisms have reported that dietary restriction (DR) is associated with an increase in mitochondrial electron transport chain (ETC) function. However, the question of whether ETC function is required for DR-mediated longevity remains controversial. Here, we report that genetic and pharmacological interventions that target mitochondrial complex V affect Drosophila lifespan in a nutrient-dependent manner. These findings support a requirement for mitochondrial complex V in DR-mediated longevity in flies.
摘要
在广泛的模式生物研究中报告称，饮食限制（DR）与线粒体电子传递链（ETC）功能的增加有关。然而，ETC 功能是否是 DR 介导的长寿所必需的问题仍然存在争议。在这里，我们报告说，针对线粒体复合物 V 的遗传和药物干预以营养依赖的方式影响果蝇的寿命。这些发现支持了线粒体复合物 V 在 DR 介导的果蝇长寿中的必要性。
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