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[使用患者健康问卷评估法国全科医疗中精神障碍的患病率:与全科医生病例识别及精神药物处方的比较]

[Prevalence of psychiatric disorders in French general practice using the patient health questionnaire: comparison with GP case-recognition and psychotropic medication prescription].

作者信息

Norton J, de Roquefeuil G, David M, Boulenger J-P, Ritchie K, Mann A

机构信息

Inserm U888, hôpital La Colombière, université Montpellier, Pavillon 42, 39, avenue Charles-Flahault, 34093 Montpellier cedex 5, France.

出版信息

Encephale. 2009 Dec;35(6):560-9. doi: 10.1016/j.encep.2008.06.018.

Abstract

INTRODUCTION

Psychiatric disorders, mainly depression and anxiety, are frequently encountered in primary care and are a major cause of distress and disability. Nearly half of cases go unnoticed and among those that are recognised, many do not receive adequate treatment. In France, there is limited research concerning the prevalence, detection and management of these conditions in primary care.

OBJECTIVES

To estimate the prevalence of psychiatric disorders, overall and for the main psychiatric diagnostic categories, encountered in primary care; to describe general practitioners' (GPs') case identification rate; to examine psychotropic medication prescription according to diagnosis, in a regionally representative sample of GP attenders.

METHODS

GP practicing standard general practice in an urban area of the city of Montpellier and a nearby semi-rural region were recruited to participate. The response rate was 32.8% (n=41). Five additional GP almost exclusively offering homeopathy and acupuncture were recruited nonrandomly for convenience purposes. In each GP surgery, consecutive patients entering the waiting room were invited by a research assistant to participate until 25 patients per GP were recruited. Each participant completed self-report questionnaires in the waiting time, including the patient health questionnaire (PHQ), which yields provisional DSM-IV diagnoses. The GP completed a brief questionnaire during the consultation, giving his/her rating of the severity of any psychiatric disorder present and action taken.

RESULTS

The patient response rate was 89.8%. In all, 14.9% of patients reached DSM-IV criteria for major depression or anxiety disorder on the PHQ (9.1% for major depression, 7.5% for panic disorder; 6% for other anxiety disorders). For the subthreshold categories, 7.4% met criteria for other depressive disorders, 11.8% for somatoform disorders and 10.9% for probable alcohol abuse or dependence. 66.3% of patients with DSM-IV diagnoses of major depression or anxiety disorder were identified by the GP as having a psychiatric disorder. The identification rate was 51% for all depressive disorders, anxiety and somatoform disorders. Of patients receiving a prescription for anxiolytic or antidepressant medication on the survey day, 80% were classified as cases of psychiatric disorder by the GP. Only 48.8% met criteria for major depression or anxiety disorder on the PHQ.

CONCLUSION

This study highlights the frequency of psychiatric disorders in a regional study of French general practice. Overall, prevalence rates were similar to those found elsewhere, except for probable alcohol abuse and dependence, which was considerably higher than in the USA PHQ validation study. As in other countries, GP identified roughly half of psychiatric cases. Furthermore, half of patients treated by anxiolytic or antidepressant medication did not meet the diagnostic criteria on the survey day for which these medications have mainly shown their efficacy. This confirms the French paradox of one of the highest psychotropic medication consumption rates in Europe despite many cases of depression remaining untreated. The PHQ could be a rapid and acceptable diagnostic aid tool for French general practice but first needs to be validated against the diagnosis of mental health professionals in this setting.

摘要

引言

精神疾病,主要是抑郁症和焦虑症,在初级保健中经常出现,是困扰和致残的主要原因。近一半的病例未被发现,而在那些被识别出的病例中,许多没有得到充分治疗。在法国,关于这些疾病在初级保健中的患病率、检测和管理的研究有限。

目的

估计在初级保健中遇到的精神疾病的总体患病率以及主要精神疾病诊断类别的患病率;描述全科医生(GP)的病例识别率;根据诊断检查在具有区域代表性的全科医生就诊者样本中精神药物的处方情况。

方法

招募在蒙彼利埃市市区和附近半农村地区从事标准全科医疗的全科医生参与。回复率为32.8%(n = 41)。为方便起见,非随机招募了另外5名几乎专门提供顺势疗法和针灸的全科医生。在每个全科医生诊所,研究助理邀请进入候诊室的连续患者参与,直到每个全科医生招募到25名患者。每位参与者在等待期间完成自我报告问卷,包括患者健康问卷(PHQ),该问卷可得出临时的DSM-IV诊断。全科医生在会诊期间完成一份简短问卷,给出其对存在的任何精神疾病严重程度的评级以及采取的行动。

结果

患者回复率为89.8%。总体而言,14.9%的患者在PHQ上达到了DSM-IV标准的重度抑郁症或焦虑症(重度抑郁症为9.1%,惊恐障碍为7.5%;其他焦虑症为6%)。对于亚阈值类别,7.4%符合其他抑郁症标准,11.8%符合躯体形式障碍标准,10.9%符合可能的酒精滥用或依赖标准。DSM-IV诊断为重度抑郁症或焦虑症的患者中,66.3%被全科医生识别为患有精神疾病。所有抑郁症、焦虑症和躯体形式障碍的识别率为51%。在调查当天接受抗焦虑或抗抑郁药物处方的患者中,80%被全科医生归类为精神疾病病例。在PHQ上只有48.8%符合重度抑郁症或焦虑症标准。

结论

这项法国全科医疗区域研究突出了精神疾病的发生率。总体而言,患病率与其他地方发现的相似,但可能的酒精滥用和依赖情况除外,其患病率远高于美国的PHQ验证研究。与其他国家一样,全科医生识别出大约一半的精神病例。此外,在调查当天接受抗焦虑或抗抑郁药物治疗的患者中,有一半不符合这些药物主要显示疗效的诊断标准。这证实了法国的一个矛盾现象,即尽管许多抑郁症病例未得到治疗,但却是欧洲精神药物消费率最高的国家之一。PHQ可能是法国全科医疗中一种快速且可接受的诊断辅助工具,但首先需要在此环境中对照心理健康专业人员的诊断进行验证。

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