土木香甲醇提取物对大鼠伤口愈合的影响。
Wound healing potential of methanolic extract of Trichosanthes dioica Roxb (fruits) in rats.
机构信息
Division of Phytochemistry and Pharmacognosy, VNS Institute of Pharmacy, Neelbud, Bhopal, MP, India.
出版信息
J Ethnopharmacol. 2010 Feb 17;127(3):614-9. doi: 10.1016/j.jep.2009.12.015. Epub 2009 Dec 16.
AIM OF THE STUDY
The present study provides a scientific evaluation for the wound healing potential of methanolic (MeOH) extract of TDR fruits.
MATERIALS AND METHODS
Excision and incision wounds were inflicted upon three groups of six rats each. Group I was assigned as control (ointment base), Group II was treated with standard silver sulfadiazine (0.01%) cream. Group III was treated with 5% MeOH extract ointment. The parameters observed were percentage of wound contraction, epithelialization period, hydroxyproline content, tensile strength including histopathological studies.
RESULTS
It was noted that the effect produced by the extract ointment showed significant (P<0.01) healing in both the wound models when compared with control group. All parameters such as wound contraction, epithelialization period, hydroxyproline content, tensile strength and histopathological studies showed significant changes when compared to control.
CONCLUSION
The result shows that TDR extract ointment demonstrates wound healing potential in both excision and incision models.
研究目的
本研究旨在对 TDR 果实的甲醇（MeOH）提取物的伤口愈合潜力进行科学评价。
材料与方法
在三组各六只大鼠上造成切除和切开伤口。第 I 组被指定为对照组（软膏基质），第 II 组用标准磺胺嘧啶银（0.01%）乳膏治疗。第 III 组用 5%甲醇提取物软膏治疗。观察的参数包括伤口收缩百分比、上皮化期、羟脯氨酸含量、拉伸强度，包括组织病理学研究。
结果
与对照组相比，软膏提取物在两种伤口模型中均产生了显著（P<0.01）的愈合效果。与对照组相比，所有参数如伤口收缩、上皮化期、羟脯氨酸含量、拉伸强度和组织病理学研究均显示出显著变化。
结论
结果表明，TDR 提取物软膏在切除和切开模型中均表现出伤口愈合潜力。
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