盘基网柄菌肌球蛋白重链激酶C的WD重复结构域在底物靶向和细胞定位中均发挥作用。
WD repeat domain of Dictyostelium myosin heavy chain kinase C functions in both substrate targeting and cellular localization.
作者信息
Franklin Atiya, Hyatt Linzi, Chowdhury Alyssa, Steimle Paul A
机构信息
Department of Biology, University of North Carolina at Greensboro, Greensboro, NC 27402, USA.
出版信息
Eukaryot Cell. 2010 Feb;9(2):344-9. doi: 10.1128/EC.00242-09. Epub 2009 Dec 11.
Abstract
Myosin II disassembly in Dictyostelium discoideum is regulated by three structurally related myosin heavy chain kinases (myosin II heavy chain kinase A [MHCK-A], -B, and -C). We show that the WD repeat domain of MHCK-C is unique in that it mediates both substrate targeting and subcellular localization, revealing a target for regulation that is distinct from those of the other MHCKs.
摘要
盘基网柄菌中的肌球蛋白II解聚由三种结构相关的肌球蛋白重链激酶（肌球蛋白II重链激酶A [MHCK-A]、-B和-C）调节。我们发现，MHCK-C的WD重复结构域具有独特性，它既能介导底物靶向，又能介导亚细胞定位，揭示了一个与其他MHCKs不同的调节靶点。
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