S100A4 与转移：小角色扮演多种角色。
S100A4 and metastasis: a small actor playing many roles.
机构信息
Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, N-0310 Oslo, Norway.
出版信息
Am J Pathol. 2010 Feb;176(2):528-35. doi: 10.2353/ajpath.2010.090526. Epub 2009 Dec 17.
Abstract
The calcium-binding protein S100A4 promotes metastasis in several experimental animal models, and S100A4 protein expression is associated with patient outcome in a number of tumor types. S100A4 is localized in the nucleus, cytoplasm, and extracellular space and possesses a wide range of biological functions, such as regulation of angiogenesis, cell survival, motility, and invasion. In this review, we summarize the evidence connecting S100A4 and cancer metastasis and discuss the mechanisms by which S100A4 promotes tumor progression.
摘要
钙结合蛋白 S100A4 可促进几种实验动物模型的转移，并且 S100A4 蛋白表达与多种肿瘤类型患者的预后相关。S100A4 定位于细胞核、细胞质和细胞外空间，并具有广泛的生物学功能，如调节血管生成、细胞存活、运动和侵袭。在这篇综述中，我们总结了连接 S100A4 和癌症转移的证据，并讨论了 S100A4 促进肿瘤进展的机制。
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