正畸牙齿移动过程中龈沟液中的瘦素水平。
Leptin levels in gingival crevicular fluid during orthodontic tooth movement.
机构信息
Department of Periodontology, Atatürk University, Erzurum, Turkey.
出版信息
Angle Orthod. 2010 May;80(3):504-8. doi: 10.2319/072109-402.1.
Abstract
OBJECTIVES
To test if leptin can be detected in the gingival crevicular fluid (GCF) around moving teeth, and to determine whether any changes occur during orthodontic tooth movement.
MATERIALS AND METHODS
An upper canine requiring distal movement served as the test tooth; the contralateral canine was used as a control tooth. The control tooth was included in the orthodontic appliance, but was not subjected to the orthodontic force. GCF sampling from the distal sites of the test and control teeth was done at baseline, 1 hour, 24 hours, and 168 hours.
RESULTS
Leptin concentrations of the test teeth decreased in a time-dependent manner. When compared with the baseline measurement, the decrease was significant at 168 hours (P < .05).
CONCLUSIONS
The concentration of leptin in GCF is decreased by orthodontic tooth movement; the results of the present study also suggest that leptin may have been one of the mediators responsible for orthodontic tooth movement.
摘要
目的
检测运动牙齿周围龈沟液（GCF）中是否存在瘦素，并确定正畸牙齿移动过程中是否发生任何变化。
材料和方法
需要远移的上颌尖牙作为实验牙，对侧尖牙作为对照牙。对照牙被纳入正畸矫治器中，但不受正畸力的作用。在基线、1 小时、24 小时和 168 小时时，从实验牙和对照牙的远中位点采集 GCF 样本。
结果
实验牙的瘦素浓度呈时间依赖性下降。与基线测量值相比，168 小时时的下降具有统计学意义（P<0.05）。
结论
正畸牙齿移动会降低 GCF 中的瘦素浓度；本研究结果还提示，瘦素可能是负责正畸牙齿移动的介质之一。
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