脂质体研究的当前趋势。

Current trends in liposome research.

作者信息

Elbayoumi Tamer A, Torchilin Vladimir P

机构信息

Department of Pharmaceutical Sciences, College of Pharmacy Glendale, Midwestern University, Glendale, AZ, USA.

出版信息

Methods Mol Biol. 2010;605:1-27. doi: 10.1007/978-1-60327-360-2_1.

DOI:10.1007/978-1-60327-360-2_1

PMID:20072870

Abstract

Among the several drug delivery systems, liposomes--phospholipid nanosized vesicles with a bilayered membrane structure--have drawn a lot of interest as advanced and versatile pharmaceutical carriers for both low and high molecular weight pharmaceuticals. At present, liposomal formulations span multiple areas, from clinical application of the liposomal drugs to the development of various multifunctional liposomal systems to be used in therapy and diagnostics. This chapter provides a brief overview of various liposomal products currently under development at experimental and preclinical level.

摘要

在几种药物递送系统中，脂质体——具有双层膜结构的磷脂纳米囊泡——作为用于低分子量和高分子量药物的先进且多功能的药物载体，引起了广泛关注。目前，脂质体制剂涵盖多个领域，从脂质体药物的临床应用到用于治疗和诊断的各种多功能脂质体系统的开发。本章简要概述了目前正在实验和临床前阶段开发的各种脂质体产品。