七价结合肺炎球菌疫苗在丹麦儿童免疫计划引入后对侵袭性肺炎球菌病的早期效果。

Early effectiveness of heptavalent conjugate pneumococcal vaccination on invasive pneumococcal disease after the introduction in the Danish Childhood Immunization Programme.

机构信息

National Neisseria and Streptococcus Reference Center, Department of Bacteriology, Mycology and Parasitology, Statens Serum Institut, Copenhagen, Denmark.

出版信息

Vaccine. 2010 Mar 19;28(14):2642-7. doi: 10.1016/j.vaccine.2010.01.017. Epub 2010 Jan 20.

DOI:10.1016/j.vaccine.2010.01.017

PMID:20096392

Abstract

We evaluated the effectiveness of the heptavalent pneumococcal conjugate vaccine (PCV7) on invasive pneumococcal disease (IPD) 1 year after PCV7's introduction in the childhood immunization programme through a nationwide cohort study based on laboratory surveillance data. There was a decline in the overall incidence of IPD from 19.4 to 17.1 cases per 100,000 population (incidence rate ratios (IRR) 0.87; 95% confidence interval (CI) [0.81-0.96]), and of meningitis from 1.56 to 1.16 (IRR 0.74; 95% CI [0.57-0.97]) comparing pre-PCV7 (years 2000-2007) and PCV7 (year 2008) periods. In children <2 years, the incidence decreased from 54 to 23 cases per 100,000 (IRR 0.43; 95% CI [0.29-0.62]) and for vaccine-serotypes from 36.7 to 7.7 (IRR 0.20; 95% CI [0.09-0.38]). The incidence of IPD declined approximately 10% (IRR 0.90; 95% CI [0.84-0.97]) in patients aged >or=2 years. The case fatality was 17% in both periods. The administration of PCV7 was followed by a marked decline in the incidence of IPD in both vaccinated and non-vaccinated individuals.

摘要

我们通过基于实验室监测数据的全国性队列研究，评估了七价肺炎球菌结合疫苗（PCV7）在儿童免疫计划中引入后 1 年对侵袭性肺炎球菌病（IPD）的有效性。总的 IPD 发病率从 19.4 例/10 万人下降到 17.1 例/10 万人（发病率比（IRR）0.87；95%置信区间（CI）[0.81-0.96]），脑膜炎从 1.56 例/10 万人下降到 1.16 例/10 万人（IRR 0.74；95%CI [0.57-0.97]），比较了 PCV7 前（2000-2007 年）和 PCV7 时期（2008 年）。在<2 岁的儿童中，发病率从 54 例/10 万人下降到 23 例/10 万人（IRR 0.43；95%CI [0.29-0.62]），疫苗血清型从 36.7 例/10 万人下降到 7.7 例/10 万人（IRR 0.20；95%CI [0.09-0.38]）。≥2 岁患者的 IPD 发病率下降了约 10%（IRR 0.90；95%CI [0.84-0.97]）。两个时期的病例病死率均为 17%。PCV7 接种后，无论是接种者还是未接种者，侵袭性肺炎球菌病的发病率都明显下降。