是否为结核病？寻找形成许可性肉芽肿的分子。

TB or not TB? Fishing for Molecules Making Permissive granulomas.

机构信息

Cluster of Excellence Inflammation-at-Interfaces, Microbial Inflammation Research, Research Center Borstel, Parkallee 1, D-23845 Borstel, Germany.

出版信息

Cell Host Microbe. 2010 Jan 21;7(1):6-8. doi: 10.1016/j.chom.2009.12.010.

DOI:10.1016/j.chom.2009.12.010

PMID:20114023

Abstract

Focal accumulations of mononuclear cells, called granulomas, are a hallmark of mycobacterial infections. A common misconception is that granulomas are uniformly protective. In transparent zebrafish larvae infected with Mycobacterium marinum, Volkman et al. demonstrate an interaction of mycobacteria with epithelial cells that helps recruit macrophages to the granuloma as "feeder cells."

摘要

单核细胞的局灶性聚集，称为肉芽肿，是分枝杆菌感染的一个标志。一个常见的误解是，肉芽肿是统一保护性的。Volkman 等人在透明斑马鱼幼虫感染分枝杆菌属的研究中表明，分枝杆菌与上皮细胞相互作用，有助于将巨噬细胞招募到肉芽肿中作为“滋养细胞”。