NOD 样受体在适应性免疫中的作用。
The role of NOD-like Receptors in shaping adaptive immunity.
机构信息
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
出版信息
Curr Opin Immunol. 2010 Feb;22(1):34-40. doi: 10.1016/j.coi.2010.01.004. Epub 2010 Feb 9.
Abstract
Not only does the innate immune system represent the first line of defense against invading pathogens, but it is also responsible for instructing appropriate adaptive immune responses. Pattern recognition receptors (PRR) detect the presence of invading pathogens and are paramount in innate instruction of the adaptive immune response. A diverse class of PRRs, the NOD-like Receptors (NLR), has recently been implicated in the regulation of processes ranging from anti-tumor immunity to the adjuvant action of aluminum hydroxide. In this review we will highlight many of the recent findings in the NLR field with a particular focus on NLR influence of adaptive immune responses.
摘要
先天免疫系统不仅是抵御入侵病原体的第一道防线，还负责指导适当的适应性免疫反应。模式识别受体 (PRR) 可检测到入侵病原体的存在，在先天指导适应性免疫反应中至关重要。最近，一类多样化的 PRR，即 NOD 样受体 (NLR)，已被牵连到从抗肿瘤免疫到氢氧化铝佐剂作用等各种过程的调节中。在这篇综述中，我们将重点介绍 NLR 领域的许多最新发现，特别关注 NLR 对适应性免疫反应的影响。
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本文引用的文献
1
Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome.
Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20388-93. doi: 10.1073/pnas.0908698106. Epub 2009 Nov 16.
2
Induction of intestinal Th17 cells by segmented filamentous bacteria.
Cell. 2009 Oct 30;139(3):485-98. doi: 10.1016/j.cell.2009.09.033.
3
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors.
Nat Med. 2009 Oct;15(10):1170-8. doi: 10.1038/nm.2028. Epub 2009 Sep 20.
4
Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma.
J Allergy Clin Immunol. 2009 Oct;124(4):779-85.e6. doi: 10.1016/j.jaci.2009.07.044. Epub 2009 Sep 19.
5
Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity.
J Immunol. 2009 Oct 1;183(7):4403-14. doi: 10.4049/jimmunol.0900164. Epub 2009 Sep 4.
6
Inflammatory role of ASC in antigen-induced arthritis is independent of caspase-1, NALP-3, and IPAF.
J Immunol. 2009 Sep 15;183(6):4003-12. doi: 10.4049/jimmunol.0802173. Epub 2009 Aug 28.
7
Toll-like receptors and innate immunity.
Biochem Biophys Res Commun. 2009 Oct 30;388(4):621-5. doi: 10.1016/j.bbrc.2009.08.062. Epub 2009 Aug 15.
8
Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors.
J Biol Chem. 2009 Sep 4;284(36):24035-48. doi: 10.1074/jbc.M109.014266. Epub 2009 Jul 15.
9
Cutting edge: Necrosis activates the NLRP3 inflammasome.
J Immunol. 2009 Aug 1;183(3):1528-32. doi: 10.4049/jimmunol.0901080. Epub 2009 Jul 13.
10
Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
J Immunol. 2009 Jul 15;183(2):787-91. doi: 10.4049/jimmunol.0901363. Epub 2009 Jul 1.
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