卡宾银配合物对生物安全3级细菌的合成及体外疗效研究
Synthesis and in vitro Efficacy Studies of Silver Carbene Complexes on Biosafety Level 3 Bacteria.
作者信息
Panzner Matthew J, Deeraksa Arpaporn, Smith Alyssa, Wright Brian D, Hindi Khadijah M, Kascatan-Nebioglu Aysegul, Torres Alfredo G, Judy Barbara M, Hovis Christine E, Hilliard Julia K, Mallett Rebekah J, Cope Emily, Estes D Mark, Cannon Carolyn L, Leid Jeff G, Youngs Wiley J
机构信息
Department of Chemistry, University of Akron, Akron, OH 44325-3601, USA.
出版信息
Eur J Inorg Chem. 2009 May 1;2009(13):1739-1745. doi: 10.1002/ejic.200801159.
Abstract
A series of N-heterocyclic carbene silver complexes have been synthesized and tested against the select group of bio-safety level 3 bacteria Burkholderia pseudomallei, Burkholderia mallei, Bacillus anthracis, methicillin-resistant Staphylococcus aureus and Yersinia pestis. Minimal inhibitory concentrations, minimal bactericidal and killing assays demonstrated the exceptional efficacy of the complexes against these potentially weaponizable pathogens.
摘要
一系列N-杂环卡宾银配合物已被合成，并针对生物安全3级细菌的选定组进行了测试，这些细菌包括类鼻疽伯克霍尔德菌、鼻疽伯克霍尔德菌、炭疽芽孢杆菌、耐甲氧西林金黄色葡萄球菌和鼠疫耶尔森菌。最低抑菌浓度、最低杀菌和杀灭试验证明了这些配合物对这些具有潜在武器化能力的病原体具有卓越的疗效。
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