Dows Institute for Dental Research, University of Iowa, 52242, USA.
Int J Mol Sci. 2010 Jan 25;11(1):354-69. doi: 10.3390/ijms11010354.
Bone adaptation or integration of an implant is characterized by a series of biological reactions that start with bone turnover at the interface (a process of localized necrosis), followed by rapid repair. The wound healing response is guided by a complex activation of macrophages leading to tissue turnover and new osteoblast differentiation on the implant surface. The complex role of implant surface topography and impact on healing response plays a role in biological criteria that can guide the design and development of future tissue-implant surface interfaces.
骨适应或植入物的整合以一系列生物反应为特征,这些反应始于界面处的骨转换(局部坏死过程),随后迅速修复。伤口愈合反应由巨噬细胞的复杂激活来引导,导致组织转换和植入物表面上新的成骨细胞分化。植入物表面形貌的复杂作用及其对愈合反应的影响在生物标准中发挥作用,这些标准可以指导未来组织-植入物表面界面的设计和开发。