用于阿尔茨海默病正电子发射断层成像的双（硫代氨基甲酰基）Cu-64 配合物。
Bis(thiosemicarbazonato) Cu-64 complexes for positron emission tomography imaging of Alzheimer's disease.
机构信息
Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia.
出版信息
J Alzheimers Dis. 2010;20(1):49-55. doi: 10.3233/JAD-2010-1359.
A bis (thiosemicarbazonato) complex radiolabeled with positron emitting Cu-64 can be used for a new and alternative method for the non-invasive diagnosis of Alzheimer's disease using positron emission tomography (PET). Most imaging agents being investigated for the diagnosis of Alzheimer's disease target amyloid-beta plaque burden but our new approach highlights altered copper homeostasis. This approach has the potential to offer complementary information to other diagnostic procedures that elucidate plaque burden.
一种用正电子发射体 Cu-64 标记的双（硫代氨基甲酸盐）配合物，可用于使用正电子发射断层扫描 (PET) 进行阿尔茨海默病的非侵入性诊断的新的替代方法。大多数正在研究的用于诊断阿尔茨海默病的成像剂针对淀粉样β斑块负担，但我们的新方法强调了铜代谢的改变。这种方法有可能为阐明斑块负担的其他诊断程序提供补充信息。
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