铜催化芳基碘代物的胍基化反应：N,N'-二取代胍的形成。

Copper-catalyzed guanidinylation of aryl iodides: the formation of N,N'-disubstituted guanidines.

机构信息

Department of Chemistry, University of South Florida, 4202 East Fowler Avenue CHE 205A, Tampa, Florida 33620, USA.

出版信息

Org Lett. 2010 Mar 19;12(6):1316-9. doi: 10.1021/ol1002175.

PMID:20170103

Abstract

A copper-catalyzed cross-coupling reaction of guanidine nitrate with aryl iodides was used for the formation of N,N'-disubstituted guanidines to be used as potential therapeutics for strokes. A relatively inexpensive commercially available guanidine salt and a series of aryl iodides together with copper iodide and N,N-diethylsalicylamide as an efficient catalyst/ligand system provided a simple diarylation procedure.

摘要

硝基金刚胍与芳基碘化物的铜催化交叉偶联反应用于形成 N,N'-二取代胍，可作为治疗中风的潜在药物。一种相对廉价的市售胍盐与一系列芳基碘化物以及碘化亚铜和 N,N-二乙基水杨酰胺作为高效催化剂/配体系统提供了一种简单的二芳基化方法。