红花花瓣中的两个新查尔酮。
Two new quinochalcones from the florets of Carthamus tinctorius.
机构信息
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing 100050, People's Republic of China.
出版信息
Org Lett. 2010 Mar 19;12(6):1196-9. doi: 10.1021/ol902971w.
Two new quinochalcone compounds, named saffloquinoside A (1) and saffloquinoside B (2), were isolated from the florets of Carthamus tinctorius. Their unusual structures including their absolute stereochemistry were elucidated based on UV, IR, HRESIMS, 1D and 2D NMR data, and CD spectrum. Saffloquinoside A has an uncommon six-five member dioxaspirocycle and saffloquinoside B has a cyclohexatrione skeleton with a benzyl group and two C-glycosyl units. Saffloquinoside A exhibited middling anti-inflammatory activity.
从红花的花瓣中分离得到了两种新的查尔酮类化合物，命名为红花甙 A（1）和红花甙 B（2）。基于 UV、IR、HRESIMS、1D 和 2D NMR 数据以及 CD 谱，阐明了它们不寻常的结构，包括绝对立体化学。红花甙 A 具有罕见的六五元双氧杂螺环，而红花甙 B 具有环己三酮骨架，带有苄基和两个 C-糖基单元。红花甙 A 表现出中等强度的抗炎活性。
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