锌补充剂对乳糜泻患者的作用——是否有必要？
Zinc supplementation to patients with celiac disease--is it required?
机构信息
Division of Pediatric Gastroenterology Hepatology and Nutrition, Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
出版信息
J Trop Pediatr. 2010 Dec;56(6):391-7. doi: 10.1093/tropej/fmq011. Epub 2010 Feb 21.
BACKGROUND AND OBJECTIVES
This study was conducted to evaluate plasma levels of zinc in children with celiac disease, to correlate plasma zinc levels among the celiacs with short stature and diarrhea and to compare plasma zinc levels in deficient patients on gluten-free diet (GFD) with or without 4 weeks of zinc supplementation.
METHODS
A total of 134 patients underwent plasma zinc estimation at baseline and after a four week period. Zinc-deficient patients were randomly assigned to two groups. Group G (n = 48) received GFD without zinc supplementation, Group G + Z (n = 48) received GFD with zinc supplementation for 4 weeks.
RESULTS
The rise in plasma Zinc levels was significant in each group regardless of zinc supplementation but similar when compared in the two groups after 4 weeks. Mean zinc levels at baseline and increase in zinc levels were statistically similar at 4 weeks in patients with diarrhea and short stature.
CONCLUSIONS
Zinc levels rise with GFD irrespective of zinc supplementation.
背景和目的
本研究旨在评估乳糜泻患儿的血浆锌水平，分析乳糜泻患儿中身材矮小和腹泻与血浆锌水平的相关性，并比较无锌补充和有锌补充的 4 周无麸质饮食（GFD）治疗的锌缺乏患者的血浆锌水平。
方法
共有 134 名患者在基线时和 4 周后进行血浆锌测定。锌缺乏患者被随机分为两组。组 G（n = 48）接受无锌补充的 GFD，组 G + Z（n = 48）接受含锌补充剂的 GFD 治疗 4 周。
结果
无论是否补充锌，各组的血浆锌水平均有显著升高，但在 4 周后两组之间的比较差异无统计学意义。腹泻和身材矮小患者在基线时的锌水平和 4 周时的锌水平增加均无统计学差异。
结论
GFD 可使锌水平升高，无论是否补充锌。
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