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[急性泛发性脓疱性皮病]

[Acute generalized exanthematous pustulosis].

作者信息

Comstedt Lisbeth Rosholm, Gregersen Janni Hjortlund, Bygum Anette

机构信息

Odense Universitetshospital, Hudafdeling I og Allergicentret, Denmark.

出版信息

Ugeskr Laeger. 2010 Feb 22;172(8):628-9.

Abstract

Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous drug reaction often caused by beta-lactam antibiotics. The reaction is characterized by sudden occurrence of a generalized exanthema, developing within 1-2 days. Hundreds of sterile pustules arise on an oedematous and erythematous base. The cutaneous symptoms are accompanied by fever and neutrophilia. The pustules resolve within 4-10 days once the causative drug has been withdrawn. We hereby present a classical case of amoxicillin-induced AGEP in a 34-year-old woman.

摘要

急性泛发性脓疱性皮病(AGEP)是一种罕见的皮肤药物反应,通常由β-内酰胺类抗生素引起。该反应的特征是在1-2天内突然出现全身性皮疹。在水肿性和红斑性基底上出现数百个无菌脓疱。皮肤症状伴有发热和中性粒细胞增多。一旦停用致病药物,脓疱在4-10天内消退。我们在此呈现一例34岁女性由阿莫西林引起的AGEP经典病例。

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