质膜中的电压依赖性阴离子选择性通道（VDAC）。

Voltage-dependent anion-selective channel (VDAC) in the plasma membrane.

机构信息

Department of Chemical Sciences, University of Catania, Istituto Nazionale di Biomembrane e Biosistemi, Sezione di Catania, Catania, Italy.

出版信息

FEBS Lett. 2010 May 3;584(9):1793-9. doi: 10.1016/j.febslet.2010.02.049. Epub 2010 Feb 23.

DOI:10.1016/j.febslet.2010.02.049

PMID:20184885

Abstract

Voltage-dependent anion channels (VDACs) have originally been characterized as mitochondrial porins. Starting in the late 1980s, however, evidence began to accumulate that VDACs can also be expressed in plasma membranes. In this review, we briefly revisit the historical milestones in the discovery of plasma membrane-bound VDAC, and we critically analyze the evidence for VDAC plasma membrane localization obtained from various purification strategies and recently from plasma membrane proteomics studies. We discuss the possible biological function and relevance of VDAC in the plasma membrane and finally discuss a hypothetical model of how VDAC may be targeted to the plasma membrane.

摘要

电压依赖性阴离子通道（VDACs）最初被描述为线粒体孔道蛋白。然而，从上世纪 80 年代末开始，越来越多的证据表明 VDAC 也可以在质膜中表达。在这篇综述中，我们简要回顾了发现质膜结合型 VDAC 的历史里程碑，并从各种纯化策略和最近的质膜蛋白质组学研究中，批判性地分析了 VDAC 质膜定位的证据。我们讨论了 VDAC 在质膜中的可能生物学功能和相关性，并最终讨论了 VDAC 靶向质膜的假设模型。