糖尿病中的血管内皮功能障碍：分子机制与临床意义。
Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications.
机构信息
Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA.
出版信息
Rev Endocr Metab Disord. 2010 Mar;11(1):61-74. doi: 10.1007/s11154-010-9134-4.
Abstract
Cardiovascular disease is a major complication of diabetes mellitus, and improved strategies for prevention and treatment are needed. Endothelial dysfunction contributes to the pathogenesis and clinical expression of atherosclerosis in diabetes mellitus. This article reviews the evidence linking endothelial dysfunction to human diabetes mellitus and experimental studies that investigated the responsible mechanisms. We then discuss the implications of these studies for current management and for new approaches for the prevention and treatment of cardiovascular disease in patients with diabetes mellitus.
摘要
心血管疾病是糖尿病的主要并发症，需要改进预防和治疗策略。内皮功能障碍是糖尿病患者动脉粥样硬化发病机制和临床表现的重要因素。本文综述了内皮功能障碍与人类糖尿病的关系，并探讨了相关的实验研究及其机制。最后讨论了这些研究对当前治疗方案的影响，以及对糖尿病患者心血管疾病预防和治疗的新方法的启示。
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