基于金纳米壳的离体人乳腺组织光热光学相干层析成像。
Photothermal optical coherence tomography in ex vivo human breast tissues using gold nanoshells.
机构信息
Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
出版信息
Opt Lett. 2010 Mar 1;35(5):700-2. doi: 10.1364/OL.35.000700.
Abstract
We demonstrate photothermal optical coherence tomography (OCT) imaging in highly scattering human breast tissue ex vivo. A 120 kHz axial scan rate, swept-source phase-sensitive OCT system at 1300 nm was used to detect phase changes induced by 830 nm photothermal excitation of gold nanoshells. Localized phase modulation was observed 300-600 microm deep in scattering tissue using an excitation power of only 22 mW at modulation frequencies up to 20 kHz. This technique enables integrated structural and molecular-targeted imaging for cancer markers using nanoshells.
摘要
我们展示了在高度散射的人体乳房组织离体样本中进行光热光学相干断层扫描（OCT）成像。使用 1300nm 的 120kHz 轴向扫描速率、扫频源相敏 OCT 系统来探测金纳米壳在 830nm 光热激发下产生的相位变化。在调制频率高达 20kHz 的情况下，仅使用 22mW 的激发功率，即可在散射组织 300-600μm 深处观察到局部的相位调制。这项技术可以使用纳米壳实现癌症标志物的结构和分子靶向成像的集成。
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