新型龋齿预防和治疗技术的专利调查。
Novel technologies for the prevention and treatment of dental caries: a patent survey.
机构信息
University of Nebraska Medical Center, College of Pharmacy, Department of Pharmaceutical Sciences, COP 3026, Omaha, NE 68198-6025, USA.
出版信息
Expert Opin Ther Pat. 2010 May;20(5):681-94. doi: 10.1517/13543771003720491.
IMPORTANCE OF THE FIELD
Dental caries is one of the most common preventable childhood diseases; people are susceptible to this ailment throughout their lifetime. In the US, 90% of late adolescents and young adults have dental caries, while 94% of all dentate adults had evidence of treated or untreated coronal caries. Dental caries is often not self-limiting and without proper care can progress until the tooth is destroyed.
AREAS COVERED IN THIS REVIEW
In this paper, the etiology of dental caries is briefly introduced. It is followed by a thorough review of patents and literatures on the recent development of various novel technologies for the prevention and treatment of dental caries.
WHAT THE READER WILL GAIN
Recent advances in anti-plaque agents, including chemoprophylactic agents, antimicrobial peptides, vaccines, probiotics/replacement therapy and sugar substitutes, and remineralization agents including fluorides and casein phosphopeptides are analyzed. TAKE HOME MASSAGE: Both the discovery of new anti-caries agents and the development of dentotropic delivery systems will be the future focus of this research field.
重要性的领域
龋齿是最常见的可预防的儿童疾病之一；人的一生都容易患这种疾病。在美国，90%的青少年和年轻人有龋齿，而所有有牙的成年人中，94%的人有治疗或未治疗的冠部龋齿的证据。龋齿往往不会自行限制，如果没有适当的护理，它会发展到牙齿被破坏。
这篇论文简要介绍了龋齿的病因。随后，对预防和治疗龋齿的各种新技术的专利和文献进行了全面回顾。
读者将获得什么
对包括化学预防剂、抗菌肽、疫苗、益生菌/替代疗法和糖替代品在内的抗菌斑剂，以及包括氟化物和酪蛋白磷酸肽在内的再矿化剂的最新进展进行了分析。
带回家的信息
新的抗龋剂的发现和牙向传递系统的发展都将是该研究领域的未来重点。
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