切换 NFIX 发育性成肌。

Switch NFix developmental myogenesis.

机构信息

Dulbecco Telethon Institute , IRCCS Fondazione Santa Lucia and European Brain Research Institute, 00161 Roma, Italy.

出版信息

Dev Cell. 2010 Mar 16;18(3):340-1. doi: 10.1016/j.devcel.2010.03.005.

DOI:10.1016/j.devcel.2010.03.005

PMID:20230743

Abstract

During development, skeletal muscles adapt to stage-specific functional and metabolic challenges by switching the expression of specific subset of genes. The mechanism that governs these changes is still enigmatic. In a recent issue of Cell, Messina and coworkers shed light on this issue through the identification of a transcription factor--NFix--that coordinates the switch in gene expression at the transition from embryonic to fetal myoblasts.

摘要

在发育过程中，骨骼肌肉通过切换特定亚群基因的表达来适应特定阶段的功能和代谢挑战。调控这些变化的机制仍然是个谜。在最近一期的《细胞》杂志上，Messina 及其同事通过鉴定一种转录因子——NFix——阐明了这一问题，NFix 协调了从胚胎成肌细胞向胎儿成肌细胞转变过程中基因表达的转换。