肽拮抗作用作为自然杀伤细胞激活的一种机制。
Peptide antagonism as a mechanism for NK cell activation.
作者信息
Fadda Lena, Borhis Gwenoline, Ahmed Parvin, Cheent Kuldeep, Pageon Sophie V, Cazaly Angelica, Stathopoulos Stavros, Middleton Derek, Mulder Arend, Claas Frans H J, Elliott Tim, Davis Daniel M, Purbhoo Marco A, Khakoo Salim I
机构信息
Divisions of Medicine and Cell and Molecular Medicine, Imperial College London, London W2 1PG, United Kingdom.
出版信息
Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10160-5. doi: 10.1073/pnas.0913745107. Epub 2010 May 3.
Abstract
Inhibition of natural killer (NK) cells is mediated by MHC class I receptors including the killer cell Ig-like receptor (KIR). We demonstrate that HLA-C binding peptides can function as altered peptide ligands for KIR and antagonize the inhibition mediated by KIR2DL2/KIR2DL3. Antagonistic peptides promote clustering of KIR at the interface of effector and target cells, but do not result in inhibition of NK cells. Our data show that, as for T cells, small changes in the peptide content of MHC class I can regulate NK cell activity.
摘要
自然杀伤（NK）细胞的抑制作用由包括杀伤细胞免疫球蛋白样受体（KIR）在内的MHC I类受体介导。我们证明，HLA - C结合肽可作为KIR的改变肽配体，并拮抗由KIR2DL2/KIR2DL3介导的抑制作用。拮抗肽促进KIR在效应细胞和靶细胞界面处聚集，但不会导致NK细胞的抑制。我们的数据表明，与T细胞一样，MHC I类肽含量的微小变化可调节NK细胞活性。
相似文献
1
Peptide antagonism as a mechanism for NK cell activation.
Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10160-5. doi: 10.1073/pnas.0913745107. Epub 2010 May 3.
2
Large spectrum of HLA-C recognition by killer Ig-like receptor (KIR)2DL2 and KIR2DL3 and restricted C1 SPECIFICITY of KIR2DS2: dominant impact of KIR2DL2/KIR2DS2 on KIR2D NK cell repertoire formation.
J Immunol. 2013 Nov 1;191(9):4778-88. doi: 10.4049/jimmunol.1301580. Epub 2013 Sep 27.
3
Allelic variation in KIR2DL3 generates a KIR2DL2-like receptor with increased binding to its HLA-C ligand.
J Immunol. 2013 Jun 15;190(12):6198-208. doi: 10.4049/jimmunol.1300464. Epub 2013 May 17.
4
Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C.
Nat Commun. 2021 Apr 12;12(1):2173. doi: 10.1038/s41467-021-22359-x.
5
B-lymphoma cells escape rituximab-triggered elimination by NK cells through increased HLA class I expression.
Exp Hematol. 2010 Mar;38(3):213-21. doi: 10.1016/j.exphem.2009.12.007. Epub 2010 Jan 6.
6
Peptide selectivity discriminates NK cells from KIR2DL2- and KIR2DL3-positive individuals.
Eur J Immunol. 2015 Feb;45(2):492-500. doi: 10.1002/eji.201444613. Epub 2014 Nov 29.
7
Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3.
J Immunol. 2008 Mar 15;180(6):3969-79. doi: 10.4049/jimmunol.180.6.3969.
8
Spatial Clustering of Receptors and Signaling Molecules Regulates NK Cell Response to Peptide Repertoire Changes.
Front Immunol. 2019 Apr 5;10:605. doi: 10.3389/fimmu.2019.00605. eCollection 2019.
9
Mutation at positively selected positions in the binding site for HLA-C shows that KIR2DL1 is a more refined but less adaptable NK cell receptor than KIR2DL3.
J Immunol. 2012 Aug 1;189(3):1418-30. doi: 10.4049/jimmunol.1100431. Epub 2012 Jul 6.
10
HLA reduces killer cell Ig-like receptor expression level and frequency in a humanized mouse model.
J Immunol. 2013 Mar 15;190(6):2880-5. doi: 10.4049/jimmunol.1200650. Epub 2013 Feb 6.
引用本文的文献
1
Peptide-specific natural killer cell receptors.
Oxf Open Immunol. 2025 Apr 17;6(1):iqaf003. doi: 10.1093/oxfimm/iqaf003. eCollection 2025.
2
Emerging mutation in SARS-CoV-2 facilitates escape from NK cell recognition and associates with enhanced viral fitness.
PLoS Pathog. 2024 Dec 9;20(12):e1012755. doi: 10.1371/journal.ppat.1012755. eCollection 2024 Dec.
3
The nuclear export protein XPO1 provides a peptide ligand for natural killer cells.
Sci Adv. 2024 Aug 23;10(34):eado6566. doi: 10.1126/sciadv.ado6566.
4
CRISPR-Cas9 screening reveals a distinct class of MHC-I binders with precise HLA-peptide recognition.
iScience. 2024 May 27;27(6):110120. doi: 10.1016/j.isci.2024.110120. eCollection 2024 Jun 21.
5
Platelet-derived major histocompatibility complex class I coating on attenuates natural killer cell lethality.
Virulence. 2024 Dec;15(1):2350892. doi: 10.1080/21505594.2024.2350892. Epub 2024 May 14.
6
The Role of Epigenetic Factors in the Pathogenesis of Psoriasis.
Int J Mol Sci. 2024 Mar 29;25(7):3831. doi: 10.3390/ijms25073831.
7
Upregulation of the NKG2D Ligand ULBP2 by JC Polyomavirus Infection Promotes Immune Recognition by Natural Killer Cells.
J Infect Dis. 2024 Jun 14;229(6):1836-1844. doi: 10.1093/infdis/jiad424.
8
NK cell education: Physiological and pathological influences.
Front Immunol. 2023 Jan 20;14:1087155. doi: 10.3389/fimmu.2023.1087155. eCollection 2023.
9
Human leukocyte antigen system associations in Malassezia-related skin diseases.
Arch Dermatol Res. 2023 May;315(4):895-902. doi: 10.1007/s00403-022-02454-9. Epub 2022 Nov 17.
10
KIR-HLA gene diversities and susceptibility to lung cancer.
Sci Rep. 2022 Oct 14;12(1):17237. doi: 10.1038/s41598-022-21062-1.
本文引用的文献
1
TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.
Nature. 2010 Feb 18;463(7283):963-7. doi: 10.1038/nature08746.
2
Features of TAP-independent MHC class I ligands revealed by quantitative mass spectrometry.
Eur J Immunol. 2008 Jun;38(6):1503-10. doi: 10.1002/eji.200838136.
3
Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3.
J Immunol. 2008 Mar 15;180(6):3969-79. doi: 10.4049/jimmunol.180.6.3969.
4
Interaction of NK inhibitory receptor genes with HLA-C and MHC class II alleles in Hepatitis C virus infection outcome.
Mol Immunol. 2008 May;45(9):2429-36. doi: 10.1016/j.molimm.2008.01.002. Epub 2008 Mar 4.
5
Cutting Edge: Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B.
J Immunol. 2007 Jan 1;178(1):33-7. doi: 10.4049/jimmunol.178.1.33.
6
Microclusters of inhibitory killer immunoglobulin-like receptor signaling at natural killer cell immunological synapses.
J Cell Biol. 2006 Jul 3;174(1):153-61. doi: 10.1083/jcb.200601108. Epub 2006 Jun 26.
7
Stable isotope tagging of epitopes: a highly selective strategy for the identification of major histocompatibility complex class I-associated peptides induced upon viral infection.
Mol Cell Proteomics. 2006 May;5(5):902-13. doi: 10.1074/mcp.T500014-MCP200. Epub 2006 Jan 23.
8
Receptor aggregation by intermembrane interactions: a Monte Carlo study.
Biophys Chem. 2006 Jan 20;119(2):205-11. doi: 10.1016/j.bpc.2005.09.019. Epub 2005 Oct 13.
9
Killer cell Ig-like receptor-dependent signaling by Ig-like transcript 2 (ILT2/CD85j/LILRB1/LIR-1).
J Immunol. 2005 Oct 15;175(8):5006-15. doi: 10.4049/jimmunol.175.8.5006.
10
Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors.
Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13224-9. doi: 10.1073/pnas.0503594102. Epub 2005 Sep 2.
Zotero 插件