SF1 和 SF2 解旋酶：家族事务。
SF1 and SF2 helicases: family matters.
机构信息
Center for RNA Molecular Biology & Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
出版信息
Curr Opin Struct Biol. 2010 Jun;20(3):313-24. doi: 10.1016/j.sbi.2010.03.011. Epub 2010 Apr 22.
Abstract
Helicases of the superfamily (SF) 1 and 2 are involved in virtually all aspects of RNA and DNA metabolism. SF1 and SF2 helicases share a catalytic core with high structural similarity, but different enzymes even within each SF perform a wide spectrum of distinct functions on diverse substrates. To rationalize similarities and differences between these helicases, we outline a classification based on protein families that are characterized by typical sequence, structural, and mechanistic features. This classification complements and extends existing SF1 and SF2 helicase categorizations and highlights major structural and functional themes for these proteins. We discuss recent data in the context of this unifying view of SF1 and SF2 helicases.
摘要
SF1 和 SF2 解旋酶几乎参与 RNA 和 DNA 代谢的各个方面。SF1 和 SF2 解旋酶具有高度结构相似性的催化核心，但即使在每个 SF 内，不同的酶在不同的底物上也执行广泛的不同功能。为了使这些解旋酶的相似性和差异性合理化，我们基于具有典型序列、结构和机制特征的蛋白质家族来概述一个分类。该分类补充并扩展了现有的 SF1 和 SF2 解旋酶分类，并强调了这些蛋白质的主要结构和功能主题。我们将在这个统一的 SF1 和 SF2 解旋酶视角下讨论最近的数据。
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