不同的方法适用于不同的情况：局灶性脑缺血动物模型的丰富多样性。
Different strokes for different folks: the rich diversity of animal models of focal cerebral ischemia.
机构信息
National Stroke Research Institute and University of Melbourne Department of Medicine, Austin Health, Melbourne, Victoria, Australia.
出版信息
J Cereb Blood Flow Metab. 2010 Aug;30(8):1412-31. doi: 10.1038/jcbfm.2010.66. Epub 2010 May 19.
Abstract
No single animal model is able to encompass all of the variables known to affect human ischemic stroke. This review highlights the major strengths and weaknesses of the most commonly used animal models of acute ischemic stroke in the context of matching model and experimental aim. Particular emphasis is placed on the relationships between outcome and underlying vascular variability, physiologic control, and use of models of comorbidity. The aim is to provide, for novice and expert alike, an overview of the key controllable determinants of experimental stroke outcome to help ensure the most effective application of animal models to translational research.
摘要
没有任何单一的动物模型能够涵盖所有已知会影响人类缺血性中风的变数。本综述主要针对模型和实验目的相匹配的情况下，突显最常被使用的急性缺血性中风动物模型的主要优缺点。特别强调的是，结果与潜在血管变异性、生理控制以及合并症模型使用之间的关系。其目的是为初学者和专家提供实验性中风结果的关键可控决定因素概述，以帮助确保动物模型在转化研究中的最有效应用。
相似文献
1
Different strokes for different folks: the rich diversity of animal models of focal cerebral ischemia.
J Cereb Blood Flow Metab. 2010 Aug;30(8):1412-31. doi: 10.1038/jcbfm.2010.66. Epub 2010 May 19.
2
Experimental models in focal cerebral ischemia: are we there yet?
Acta Neurochir Suppl. 2002;83:55-9. doi: 10.1007/978-3-7091-6743-4_10.
3
Endovascular Ischemic Stroke Models in Nonhuman Primates.
Neurotherapeutics. 2018 Jan;15(1):146-155. doi: 10.1007/s13311-017-0586-z.
4
Acute ischemic stroke: overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia.
Pharmacol Biochem Behav. 2007 May;87(1):179-97. doi: 10.1016/j.pbb.2007.04.015. Epub 2007 May 4.
5
Rodent Models of Developmental Ischemic Stroke for Translational Research: Strengths and Weaknesses.
Neural Plast. 2019 Apr 4;2019:5089321. doi: 10.1155/2019/5089321. eCollection 2019.
6
Present status and future challenges of electroencephalography- and magnetic resonance imaging-based monitoring in preclinical models of focal cerebral ischemia.
Brain Res Bull. 2014 Mar;102:22-36. doi: 10.1016/j.brainresbull.2014.01.003. Epub 2014 Jan 23.
7
A focal embolic model of cerebral ischemia in rats: introduction and evaluation.
Brain Res Brain Res Protoc. 2001 Jun;7(2):115-20. doi: 10.1016/s1385-299x(01)00049-6.
8
Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability.
J Vis Exp. 2016 Feb 23(108):53106. doi: 10.3791/53106.
9
Focal cerebral ischemia.
Methods Mol Biol. 2012;788:29-42. doi: 10.1007/978-1-61779-307-3_3.
10
Heads and Tails of Natriuretic Peptides: Neuroprotective Role of Brain Natriuretic Peptide.
J Am Heart Assoc. 2017 Dec 4;6(12):e007329. doi: 10.1161/JAHA.117.007329.
引用本文的文献
1
OCT-PAM dual-mode imaging to evaluate early ischemic stroke in rats.
J Cereb Blood Flow Metab. 2025 Aug 20:271678X251369613. doi: 10.1177/0271678X251369613.
2
New insights into acute ischemic stroke from the perspective of spatial omics.
Theranostics. 2025 Jul 11;15(15):7902-7924. doi: 10.7150/thno.113396. eCollection 2025.
3
A novel model of light-induced middle cerebral artery occlusion and recanalization in mice.
Commun Biol. 2025 Jul 28;8(1):1117. doi: 10.1038/s42003-025-08398-w.
4
Transcriptional characterization of sepsis in a LPS porcine model.
Mol Genet Genomics. 2025 Jun 5;300(1):57. doi: 10.1007/s00438-025-02261-7.
5
Therapeutic Potential of Mesenchymal Stem Cells in Stroke Treatment.
Biomolecules. 2025 Apr 10;15(4):558. doi: 10.3390/biom15040558.
6
New approach to control ischemic severity ex vivo.
J Neurosci Methods. 2025 Jan;413:110321. doi: 10.1016/j.jneumeth.2024.110321. Epub 2024 Nov 10.
7
Astrocytes in stroke-induced neurodegeneration: a timeline.
Front Mol Med. 2023 Sep 7;3:1240862. doi: 10.3389/fmmed.2023.1240862. eCollection 2023.
8
Hippocampal infarction and generalized seizures predict early mortality after endovascular middle cerebral artery occlusion in mice.
Exp Neurol. 2024 Oct;380:114903. doi: 10.1016/j.expneurol.2024.114903. Epub 2024 Jul 28.
9
Spatiotemporally selective astrocytic ATP dynamics encode injury information sensed by microglia following brain injury in mice.
Nat Neurosci. 2024 Aug;27(8):1522-1533. doi: 10.1038/s41593-024-01680-w. Epub 2024 Jun 11.
10
Ameliorative Effect of Natural Sesquiterpene Alcohol Cedrol Against Cerebral Ischemia Infarction-In Vitro and In Vivo Studies.
Appl Biochem Biotechnol. 2024 Nov;196(11):8026-8042. doi: 10.1007/s12010-024-04965-9. Epub 2024 Apr 26.
本文引用的文献
1
Annexin A2 combined with low-dose tPA improves thrombolytic therapy in a rat model of focal embolic stroke.
J Cereb Blood Flow Metab. 2010 Jun;30(6):1137-46. doi: 10.1038/jcbfm.2009.279. Epub 2010 Jan 13.
2
Inducing stroke in aged, hypertensive, diabetic rats.
J Cereb Blood Flow Metab. 2010 Apr;30(4):729-33. doi: 10.1038/jcbfm.2009.273. Epub 2010 Jan 13.
3
Severe blood-brain barrier disruption and surrounding tissue injury.
Stroke. 2009 Dec;40(12):e666-74. doi: 10.1161/STROKEAHA.109.551341. Epub 2009 Nov 5.
4
Relative risks for stroke by age, sex, and population based on follow-up of 18 European populations in the MORGAM Project.
Stroke. 2009 Jul;40(7):2319-26. doi: 10.1161/STROKEAHA.109.547869. Epub 2009 Jun 11.
5
Dose-related neuroprotective versus neurodamaging effects of estrogens in rat cerebral ischemia: a systematic analysis.
J Cereb Blood Flow Metab. 2009 Aug;29(8):1359-72. doi: 10.1038/jcbfm.2009.66. Epub 2009 May 20.
6
Body and brain temperature coupling: the critical role of cerebral blood flow.
J Comp Physiol B. 2009 Aug;179(6):701-10. doi: 10.1007/s00360-009-0352-6. Epub 2009 Mar 11.
7
Surgical decompression for space-occupying cerebral infarction (the Hemicraniectomy After Middle Cerebral Artery infarction with Life-threatening Edema Trial [HAMLET]): a multicentre, open, randomised trial.
Lancet Neurol. 2009 Apr;8(4):326-33. doi: 10.1016/S1474-4422(09)70047-X. Epub 2009 Mar 5.
8
Update of the stroke therapy academic industry roundtable preclinical recommendations.
Stroke. 2009 Jun;40(6):2244-50. doi: 10.1161/STROKEAHA.108.541128. Epub 2009 Feb 26.
9
Age at natural menopause and risk of ischemic stroke: the Framingham heart study.
Stroke. 2009 Apr;40(4):1044-9. doi: 10.1161/STROKEAHA.108.542993. Epub 2009 Feb 20.
10
Experimental models: help or hindrance.
Stroke. 2009 Mar;40(3 Suppl):S152-4. doi: 10.1161/STROKEAHA.108.533505. Epub 2008 Dec 8.
Zotero 插件