与恶性疟原虫相比，间日疟原虫引起更大的内皮细胞激活、血小板 - 内皮细胞颗粒释放和宿主炎症反应：印度尼西亚巴布亚的一项前瞻性研究。
Greater endothelial activation, Weibel-Palade body release and host inflammatory response to Plasmodium vivax, compared with Plasmodium falciparum: a prospective study in Papua, Indonesia.
机构信息
International Health Division, Menzies School of Health Research and Charles Darwin University, and Division of Medicine, Royal Darwin Hospital, Darwin, NT, Australia.
出版信息
J Infect Dis. 2010 Jul 1;202(1):109-12. doi: 10.1086/653211.
Abstract
Pathogenic mechanisms underlying vivax malaria are poorly understood, with few studies comparing endothelial and inflammatory responses with falciparum malaria. In adults with uncomplicated vivax or falciparum malaria, we compared plasma measurements of endothelial Weibel-Palade body release (angiopoietin-2) and activation (ICAM-1, E-selectin), as well as selected cytokines. Despite a lower median parasite count, angiopoietin-2 concentrations were higher in patients with vivax malaria, compared with falciparum malaria. Per peripheral parasite, median plasma angiopoietin-2, ICAM-1, E-selectin, interleukin-6, and interleukin-10 concentrations were higher in patients with malaria due to Plasmodium vivax. P. vivax induces greater endothelial Weibel-Palade body release and activation and greater host inflammatory responses, compared with Plasmodium falciparum.
摘要
导致间日疟的发病机制尚未完全明了，比较恶性疟和间日疟的内皮细胞和炎症反应的研究较少。我们比较了无并发症的间日疟和恶性疟患者的血浆内皮魏尔啸体释放（血管生成素-2）和激活（细胞间黏附分子-1、E-选择素）以及部分细胞因子的测量值。尽管寄生虫载量中位数较低，但与恶性疟相比，间日疟患者的血管生成素-2浓度更高。每存在一个外周寄生虫，间日疟患者的血浆血管生成素-2、细胞间黏附分子-1、E-选择素、白细胞介素-6 和白细胞介素-10 浓度中位数均高于恶性疟患者。与恶性疟原虫相比，间日疟原虫诱导更大的内皮魏尔啸体释放和激活以及更强的宿主炎症反应。
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