希腊中部风湿性疾病的流行情况：一项人群调查。
The prevalence of rheumatic diseases in central Greece: a population survey.
机构信息
Department of Rheumatology and Biomathematics, Thessaly University School of Medicine and Hospital, Larissa 41 110, Greece.
出版信息
BMC Musculoskelet Disord. 2010 May 26;11:98. doi: 10.1186/1471-2474-11-98.
BACKGROUND
Rheumatic diseases are a major health and financial burden for societies. The prevalence of rheumatic diseases may change over time, and therefore, we sought to estimate the prevalence of rheumatic diseases in an adult population of central Greece.
METHODS
In this prospective cross-sectional population survey, a random sample of adult population was drawn from poll catalogues of a region in central Greece. A postal questionnaire was sent to 3,528 people for the presence of any rheumatic disease. All positive cases were further confirmed by clinical examination using the American College of Rheumatoloy criteria. Multiple regression analysis was used to assess risk factors for rheumatic diseases.
RESULTS
The response rate was 48.3% (1,705 answers). Four hundred and twenty individuals (24.6%) had a rheumatic disease. The prevalence of rheumatoid arthritis was 0.58% (95% confidence interval [CI], 0.32-0.87), of psoriatic arthritis was 0.35% (95% CI, 0.33-1.13), of ankylosing spondylitis was 0.29% (95% CI, 0.28-0.94), of primary Sjögren's syndrome was 0.23% (95% CI, 0.22-0.75) and of systemic lupus erythematosus was 0.11% (95% CI, 0.11-0.37). One individual had systemic sclerosis (prevalence, 0.058%), 1 individual had dermatomyositis (prevalence, 0.058%; 95% CI, 0.05-0.18), 2 individuals had vasculitis (prevalence 0.11%; 95% CI, 0.11-0.37), 81 individuals had gout (prevalence, 4.75%; 95% CI, 4.41-5.13), and 304 individuals had osteoarthritis (OA) (prevalence 17.82%; 95% CI, 16.50-19.34). Gout was associated with male gender, diabetes mellitus, and hypertension, and OA was associated with age, female gender, and hypertension.
CONCLUSIONS
Rheumatic diseases are common in central Greece, affecting nearly a quarter of adult population. OA and gout are the most common joint disorders.
背景
风湿性疾病是社会的主要健康和经济负担。风湿性疾病的患病率可能随时间而变化，因此，我们试图估计希腊中部地区成年人群中的风湿性疾病患病率。
方法
在这项前瞻性横断面人群调查中，从希腊中部一个地区的选民登记册中抽取了成年人群的随机样本。向 3528 人发送了一份邮寄问卷，以了解是否存在任何风湿性疾病。所有阳性病例均通过美国风湿病学会标准的临床检查进一步证实。多因素回归分析用于评估风湿性疾病的危险因素。
结果
应答率为 48.3%（1705 份答卷）。420 人（24.6%）患有风湿性疾病。类风湿关节炎的患病率为 0.58%（95%可信区间，0.32-0.87），银屑病关节炎为 0.35%（95%可信区间，0.33-1.13），强直性脊柱炎为 0.29%（95%可信区间，0.28-0.94），原发性干燥综合征为 0.23%（95%可信区间，0.22-0.75），系统性红斑狼疮为 0.11%（95%可信区间，0.11-0.37）。1 例患者患有系统性硬化症（患病率 0.058%），1 例患者患有皮肌炎（患病率 0.058%；95%可信区间，0.05-0.18），2 例患者患有血管炎（患病率 0.11%；95%可信区间，0.11-0.37），81 例患者患有痛风（患病率 4.75%；95%可信区间，4.41-5.13），304 例患者患有骨关节炎（OA）（患病率 17.82%；95%可信区间，16.50-19.34）。痛风与男性、糖尿病和高血压有关，OA 与年龄、女性和高血压有关。
结论
风湿性疾病在希腊中部很常见，影响了近四分之一的成年人群。OA 和痛风是最常见的关节疾病。
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