Department of Internal Medicine, Geriatric Medicine Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
Health Qual Life Outcomes. 2010 Jun 8;8:56. doi: 10.1186/1477-7525-8-56.
There is a lack of knowledge concerning the relationship between two closely-linked multidimensional variables: frailty and quality of life (QOL). The aim of this study was to investigate dimensions and correlates of QOL associated with frailty status among community-dwelling older outpatients.
We conducted a cross-sectional survey of 239 community-dwelling outpatients aged 65+ (mean age 81.5 years) consecutively referred to a geriatric medicine clinic in Italy between June and November 2009. Participants underwent a comprehensive geriatric assessment, including assessment of their frailty status according to the Study of Osteoporotic Fractures (SOF) criteria, and QOL, which was evaluated by using the Older People's QOL (OPQOL) questionnaire. One-way ANOVA and chi-squared tests were used to find correlates of frailty, including QOL dimensions, after stratification of participants in the "robust" (n = 72), "pre-frail" (n = 89) and "frail" (n = 78) groups. Multiple linear regression analyses were performed to find correlates of QOL in the overall sample and among "frail" and "robust" participants.
A negative trend of QOL with frailty status was found for almost all dimensions of QOL (health, independence, home and neighbourhood, psychological and emotional well-being, and leisure, activities and religion) except for social relationships and participation and financial circumstances. Independent correlates of a poor QOL in the total sample were "reduced energy level" (SOF criterion for frailty), depressive status, dependence in transferring and bathing abilities and money management (adjusted R squared 0.39); among "frail" participants the associations were with depressive status and younger age, and among "robust" participants the association was with lower body mass index.
Five out of seven dimensions of QOL were negatively affected by frailty, but only one SOF criterion for frailty was independently related to QOL, after correction for age, functional status and depression. A more advanced age as well as a better affective status were correlates of a better QOL among frail elders. Interventions targeting the QOL in frail community-dwelling older outpatients should consider as outcomes, not only health-related QOL, but also other domains of the QOL.
人们对两个密切相关的多维变量之间的关系知之甚少:衰弱和生活质量(QOL)。本研究的目的是调查与社区居住的老年门诊患者衰弱状况相关的 QOL 维度及其相关性。
我们对 2009 年 6 月至 11 月间连续到意大利老年医学诊所就诊的 239 名社区居住的 65 岁以上(平均年龄 81.5 岁)门诊患者进行了横断面调查。参与者接受了全面的老年评估,包括根据骨质疏松性骨折研究(SOF)标准评估其衰弱状况,以及使用老年人生活质量(OPQOL)问卷评估 QOL。在将参与者分为“强壮”(n = 72)、“虚弱前期”(n = 89)和“虚弱”(n = 78)组后,使用单向方差分析和卡方检验来寻找与衰弱相关的因素,包括 QOL 维度。对所有样本以及“虚弱”和“强壮”参与者进行了多元线性回归分析,以寻找 QOL 的相关性。
在几乎所有 QOL 维度(健康、独立性、家庭和邻里、心理和情绪健康以及休闲、活动和宗教)中,QOL 随着衰弱状况的恶化呈现出负趋势,除了社会关系和参与度以及经济状况。在总样本中,QOL 较差的独立相关因素是“能量水平降低”(SOF 衰弱标准)、抑郁状态、转移和洗澡能力以及财务管理依赖(调整后的 R 平方为 0.39);在“虚弱”参与者中,与抑郁状态和年龄较小相关,而在“强壮”参与者中,与较低的体重指数相关。
在 QOL 的七个维度中,有五个维度受到衰弱的负面影响,但只有一个 SOF 衰弱标准与 QOL 独立相关,经过年龄、功能状态和抑郁的校正后。在虚弱的社区居住的老年门诊患者中,更先进的年龄以及更好的情感状态是 QOL 更好的相关因素。针对虚弱的社区居住的老年门诊患者的 QOL 干预措施,应将健康相关的 QOL 以及其他 QOL 领域作为结果来考虑。