Rodriguez Keri L, Hanlon Joseph T, Perera Subashan, Jaffe Emily J, Sevick Mary Ann
Center for Health Equity Research and Promotion, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA.
Am J Geriatr Pharmacother. 2010 Jun;8(3):225-32. doi: 10.1016/j.amjopharm.2010.05.002.
Approximately 25% of all US deaths occur in the long-term care setting, and this figure is projected to rise to 40% by the year 2040. Currently, there is limited information on nonpain symptoms and their appropriate treatment in this setting at the end of life.
This study evaluated the prevalence of undertreatment of nonpain symptoms and factors associated with undertreatment in older nursing home hospice/palliative care patients.
This study used a cross-sectional sample of older (>or=65 years) hospice/palliative care patients to represent all patients from the 2004 National Nursing Home Survey (NNHS) funded by the Centers for Disease Control and Prevention. Nonpain symptoms were determined from facility staff, who used the medical records to answer questions about the residents. Data on medication use were derived from medication administration records. Undertreatment was defined as the omission of a necessary medication for a specific nonpain symptom and was evaluated as a dichotomous variable (yes = the nonpain symptom was not treated with a medication; no = the nonpain symptom was treated with a medication). Cross-sectional bivariate analyses were conducted using chi(2) and regression coefficient tests to determine factors potentially associated with undertreatment of nonpain symptoms.
The cross-sectional sample included 303 older nursing home hospice/palliative care patients from among the 33,413 (weighted) patients from the 2004 NNHS. Overall, most of the patients were white (91.4% [277/303]) and female (71.9% [218/303]), and nearly half were aged >or=85 years (47.9% [145/303]). One or more nonpain symptoms occurred in 82 patients (22.0% weighted). The most common nonpain symptoms (weighted percentages) were constipation/fecal impaction in 35 patients (8.8%), cough in 34 patients (9.2%), nausea/vomiting in 26 patients (7.2%), fever in 11 patients (3.1%), and diarrhea in 9 patients (1.9%). Medication undertreatment of any of the above symptoms was seen in 47 of 82 patients (60.0% weighted), ranging from a low of 26.4% for constipation/ fecal impaction to a high of 88.0% for nausea/vomiting. Undertreated patients had significantly more problems with bed mobility (n [weighted %], 43 [92.3%] vs 21 [67.2%]; P = 0.013), mood (21 [44.7%] vs 7 [19.7%]; P = 0.017), and pressure ulcers (12 [25.7%] vs 2 [6.1%]; P = 0.023) than did treated patients. The undertreated group also had a significantly greater number of secondary diagnoses (weighted mean [SD], 6.5 [0.7] vs 5.2 [0.5]; P = 0.004) but had a shorter length of stay in hospice/ palliative care (120.5 [20.1] vs 219.4 [51.8] days; P < 0.001) or in the nursing home (552.0 [96.5] vs 1285.4 [268.3] days; P = 0.001).
The prevalence of nonpain symptoms was low (22.0% weighted) in older nursing home hospice/palliative care patients. However, medication undertreatment of nonpain symptoms was seen in more than half of these patients. Future quality-improvement initiatives for nursing home hospice/palliative care patients are needed beyond the management of pain symptoms.
在美国,约25%的死亡发生在长期护理机构,预计到2040年这一数字将升至40%。目前,关于临终时该环境下非疼痛症状及其适当治疗的信息有限。
本研究评估了老年疗养院临终关怀/姑息治疗患者非疼痛症状治疗不足的患病率以及与治疗不足相关的因素。
本研究采用横断面抽样,选取年龄≥65岁的临终关怀/姑息治疗患者,以代表2004年由疾病控制与预防中心资助的全国疗养院调查(NNHS)中的所有患者。非疼痛症状由机构工作人员根据病历回答有关居民的问题来确定。用药数据来自用药管理记录。治疗不足定义为未使用针对特定非疼痛症状的必要药物,并作为二分变量进行评估(是 = 非疼痛症状未用药治疗;否 = 非疼痛症状用药治疗)。采用卡方检验和回归系数检验进行横断面双变量分析,以确定可能与非疼痛症状治疗不足相关的因素。
横断面样本包括2004年NNHS的33413名(加权)患者中的303名老年疗养院临终关怀/姑息治疗患者。总体而言,大多数患者为白人(91.4%[277/303])和女性(71.9%[218/303]),近一半年龄≥85岁(47.9%[145/303])。82名患者(加权患病率22.0%)出现一种或多种非疼痛症状。最常见的非疼痛症状(加权百分比)为便秘/粪便嵌塞35例(8.8%)、咳嗽34例(9.2%)、恶心/呕吐26例(7.2%)、发热11例(- 3.1%)和腹泻9例(1.9%)。82例患者中有47例(加权患病率60.0%)上述任何症状存在药物治疗不足,便秘/粪便嵌塞的最低治疗不足率为26.4%,恶心/呕吐的最高治疗不足率为88.0%。与接受治疗的患者相比,治疗不足的患者在床活动能力方面问题显著更多(n[加权%],43[92.3%]对21[67.2%];P = 0.013)、情绪方面问题显著更多(21[44.7%]对7[19.7%];P = 0.017)以及压疮方面问题显著更多(12[25.7%]对2[6.1%];P = 0.023)。治疗不足组的二级诊断数量也显著更多(加权均值[标准差],6.5[0.7]对5.2[0.5];P = 0.004),但在临终关怀/姑息治疗中的住院时间较短(120.5[20.1]天对219.4[51.8]天;P < 0.001)或在疗养院中的住院时间较短(552.0[96.5]天对1285.4[268.3]天;P = 0.001)。
老年疗养院临终关怀/姑息治疗患者中非疼痛症状的患病率较低(加权患病率22.0%)。然而,超过一半的患者存在非疼痛症状的药物治疗不足。除了疼痛症状管理之外,未来还需要针对疗养院临终关怀/姑息治疗患者开展质量改进举措。