亚甲基四氢叶酸还原酶 (C677T) 多态性与大动脉粥样硬化性缺血性卒中亚型。

Methylenehydrofolate reductase (C677T) polymorphism and large artery ischemic stroke subtypes.

机构信息

Hassan II University, Ibn Rochd Hospital, District Hospitals, Casablanca, Morocco.

出版信息

Acta Neurol Scand. 2011 Feb;123(2):105-10. doi: 10.1111/j.1600-0404.2010.01348.x.

DOI:10.1111/j.1600-0404.2010.01348.x

PMID:20637011

Abstract

BACKGROUND

The role for the methylenetetrahydrofolate reductase C677T gene variants in the risk of ischemic stroke is controversial.

METHOD

This first case-control study including 91 cases affected by ischemic stroke and 182 controls matched for age, sex, and same area was conducted in Casablanca, Morocco. Allele and genotype frequency were characterized by using PCR followed by HinfI enzymatic digestion.

RESULTS

We found no statistic association of T allele carriers genetic factors with stroke; odds ratio, 1.1; 95% confidence interval (CI), 0.59-2.04, P = 0.303. The results shown significant association of T allele carriers genetic factors with atherothrombotic subtype stroke (n = 42); odds ratio, 2.1; 95% CI: 1.17-3.8; P = 0.012, and adjusted odds ratio of 6.5; 95% CI: 1.86-23.1, P = 0.003, for TT genotype variant compared with CC wild genotype.

CONCLUSION

We suggested that MTHFR C677T variant may be a determinant of atherothrombotic event of ischemic stroke in Morocco.

摘要

背景

亚甲基四氢叶酸还原酶 C677T 基因变异与缺血性脑卒中风险的关系存在争议。

方法

这是一项在摩洛哥卡萨布兰卡进行的首例病例对照研究，共纳入 91 例缺血性脑卒中患者和 182 例年龄、性别和同地区匹配的对照组。采用 PCR 结合 HinfI 酶切法检测等位基因和基因型频率。

结果

我们发现 T 等位基因携带者的遗传因素与脑卒中之间无统计学关联；比值比为 1.1；95%置信区间（CI）为 0.59-2.04，P = 0.303。结果显示 T 等位基因携带者的遗传因素与动脉粥样硬化血栓形成型脑卒中（n = 42）显著相关；比值比为 2.1；95%CI：1.17-3.8；P = 0.012，与 CC 野生基因型相比，TT 基因型变异的调整比值比为 6.5；95%CI：1.86-23.1，P = 0.003。