饮茶和咖啡与黑人女性健康研究中乳腺癌风险的关系。
Tea and coffee intake in relation to risk of breast cancer in the Black Women's Health Study.
机构信息
Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, Boston, MA 02215, USA.
出版信息
Cancer Causes Control. 2010 Nov;21(11):1941-8. doi: 10.1007/s10552-010-9622-6. Epub 2010 Aug 3.
OBJECTIVE
Prospective studies of tea and coffee intake and breast cancer risk have yielded inconsistent results. None of these studies has reported separately on African-American women. We prospectively examined the relation of tea and coffee consumption to risk of breast cancer among 52,062 women aged 21-69 at enrollment in 1995 in the Black Women's Health Study.
METHODS
Dietary intake was assessed in 1995 and 2001 using a validated food frequency questionnaire. Cox proportional hazards models were used to estimate incidence rate ratios (IRR) and 95% confidence intervals (CI), adjusted for breast cancer risk factors.
RESULTS
During 12 years of follow-up through 2007, there were 1,268 incident cases of breast cancer. Intakes of tea, coffee, and caffeine were not significantly associated with the risk of breast cancer overall. The IRRs for consumption of ≥4 cups/day compared with none were 1.13 (95% CI 0.78-1.63) for tea and 1.03 (95% CI 0.77-1.39) for caffeinated coffee, and the IRR for the top quintile relative to the bottom quintile of caffeine intake was 1.04 (95% CI 0.87-1.24). Consumption of tea, coffee, and caffeine was not significantly associated with breast cancer risk according to menopausal status or hormone receptor status.
CONCLUSION
Our findings suggest that intakes of tea, coffee, and caffeine are not associated with the risk of breast cancer among African-American women.
目的
茶和咖啡摄入与乳腺癌风险的前瞻性研究结果不一致。这些研究均未分别报告非裔美国女性的情况。我们前瞻性地研究了 52062 名年龄在 21-69 岁的黑人女性，她们于 1995 年参加黑人女性健康研究时报告了茶和咖啡的消费情况，并随访至 2007 年发生乳腺癌的情况。
方法
1995 年和 2001 年使用经过验证的食物频率问卷评估饮食摄入量。使用 Cox 比例风险模型估计发病率比（IRR）和 95％置信区间（CI），并根据乳腺癌危险因素进行调整。
结果
在 12 年的随访期间（截至 2007 年），共发生 1268 例乳腺癌新发病例。茶、咖啡和咖啡因的摄入量与乳腺癌的总体风险无显著相关性。与不饮用相比，≥4 杯/天的茶和含咖啡因咖啡的 IRR 分别为 1.13（95％CI 0.78-1.63）和 1.03（95％CI 0.77-1.39），而咖啡因摄入量最高五分位组相对于最低五分位组的 IRR 为 1.04（95％CI 0.87-1.24）。根据绝经状态或激素受体状态，茶、咖啡和咖啡因的消耗与乳腺癌风险均无显著相关性。
结论
我们的研究结果表明，非裔美国女性的茶、咖啡和咖啡因摄入量与乳腺癌风险无关。
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