HER2 断裂与乳腺癌分层。
HER2 fragmentation and breast cancer stratification.
机构信息
Vall d'Hebron Institute of Oncology, Barcelona, Spain.
出版信息
Clin Cancer Res. 2010 Aug 15;16(16):4071-3. doi: 10.1158/1078-0432.CCR-10-1501. Epub 2010 Aug 3.
Abstract
HER2 is a tyrosine kinase receptor whose overexpression in breast cancers correlates with poor prognosis. A subset of HER2-positive tumors also expresses a series of HER2 fragments, collectively known as p95HER2. These fragments are emerging as a valuable biomarker for this subset of patients, who have a particularly poor prognosis.
摘要
HER2 是一种酪氨酸激酶受体，其在乳腺癌中的过度表达与预后不良相关。HER2 阳性肿瘤的亚组还表达一系列 HER2 片段，统称为 p95HER2。这些片段正成为这部分患者的一个有价值的生物标志物，这些患者的预后特别差。
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