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综述文章:创伤性脑损伤后颅内压升高的手术治疗方法。

Review article: the surgical approach to the management of increased intracranial pressure after traumatic brain injury.

机构信息

Academic Neurosurgery Unit, University of Cambridge/Addenbrooks Hospital, Cambridge, CB2 0QH, UK.

出版信息

Anesth Analg. 2010 Sep;111(3):736-48. doi: 10.1213/ANE.0b013e3181e75cd1. Epub 2010 Aug 4.

Abstract

Increased intracranial pressure occurring after severe traumatic brain injury is a common and potentially devastating phenomenon. It has been clearly demonstrated that increased intracranial pressure that is refractory to initial medical measures is a poor prognostic sign. Current optimal management is based on a sequential, target-driven approach combining both medical and surgical treatment strategies. The surgical measures in current common practice include external ventricular drain insertion and decompressive craniectomy. There is evidence that both of these measures reduce intracranial pressure but the effect on outcome, particularly in the long term, is equivocal. Current Brain Trauma Foundation guidelines recommend timely evacuation of mass lesions and there is clear guidance regarding the indications for intracranial pressure monitoring; however, decompressive craniectomy is only cautiously recommended as a possible option for selected patients. In this review, we highlight the ongoing debate about the use of decompressive craniectomy to control intracranial pressure after traumatic brain injury; included is a summary of review of the most recent literature on the effect of decompressive craniectomy on increased intracranial pressure after traumatic brain injury and associated long-term outcome. The RESCUEicp and DECRA studies are discussed in detail. It is hoped that these 2 randomized controlled trials, which are evaluating the short- and longer-term outcomes of decompressive craniectomy, will provide conclusive evidence regarding the role of decompressive craniectomy in managing increased intracranial pressure after trauma.

摘要

颅脑创伤后发生的颅内压升高是一种常见且潜在致命的现象。已经明确表明,初始药物治疗无法控制的颅内压升高是预后不良的标志。目前的最佳治疗方法基于一种序贯、靶向的方法,结合了药物和手术治疗策略。目前常见的手术措施包括脑室外引流和去骨瓣减压术。有证据表明,这两种措施都可以降低颅内压,但对结果的影响,尤其是长期影响,尚无定论。目前的脑外伤基金会指南建议及时清除肿块病变,并且对颅内压监测的适应证有明确的指导;然而,去骨瓣减压术仅被谨慎推荐为某些患者的可能选择。在这篇综述中,我们强调了关于使用去骨瓣减压术控制颅脑创伤后颅内压的持续争论;包括对最近关于去骨瓣减压术对颅脑创伤后颅内压升高和相关长期结果影响的文献综述的总结。详细讨论了 RESCUEicp 和 DECRA 研究。希望这两项正在评估去骨瓣减压术短期和长期结局的随机对照试验,能为去骨瓣减压术在创伤后管理颅内压升高方面的作用提供确凿的证据。

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