自然杀伤细胞的教育与耐受。
Natural killer cell education and tolerance.
机构信息
Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, CA 94143, USA.
出版信息
Cell. 2010 Sep 17;142(6):847-56. doi: 10.1016/j.cell.2010.08.031.
Abstract
Natural killer (NK) cells play a key role in the immune response to certain infections and malignancies by direct cytolysis of infected or transformed cells and by secretion of potent immune mediators. NK cells express an array of activating receptors that recognize self-molecules. If not restrained by inhibitory receptors recognizing major histocompatibility complex (MHC) class I proteins on the surface of self cells, NK cells are able to kill normal, healthy cells. Not all NK cells express inhibitory receptors for self-MHC class I; thus, other tolerance mechanisms are necessary to prevent NK cell-mediated autoimmunity. Here we review the major mechanisms of NK cell education and tolerance.
摘要
自然杀伤 (NK) 细胞通过直接溶解感染或转化的细胞以及分泌有效的免疫介质，在对某些感染和恶性肿瘤的免疫反应中发挥关键作用。NK 细胞表达一系列识别自身分子的激活受体。如果不受识别自身细胞表面主要组织相容性复合体 (MHC) 类 I 蛋白的抑制性受体的限制，NK 细胞能够杀死正常的健康细胞。并非所有的 NK 细胞都表达自身 MHC 类 I 的抑制性受体；因此，需要其他耐受机制来防止 NK 细胞介导的自身免疫。本文综述了 NK 细胞教育和耐受的主要机制。
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本文引用的文献
1
Effect of NKG2D ligand expression on host immune responses.
Immunol Rev. 2010 May;235(1):267-85. doi: 10.1111/j.0105-2896.2010.00893.x.
2
Intact NKG2D-independent function of NK cells chronically stimulated with the NKG2D ligand Rae-1.
J Immunol. 2010 Jul 1;185(1):157-65. doi: 10.4049/jimmunol.1000397. Epub 2010 Jun 7.
3
Innate immunity defines the capacity of antiviral T cells to limit persistent infection.
J Exp Med. 2010 Jun 7;207(6):1333-43. doi: 10.1084/jem.20091193. Epub 2010 May 31.
4
Effects of MHC class I alleles on licensing of Ly49A+ NK cells.
J Immunol. 2010 Apr 1;184(7):3424-32. doi: 10.4049/jimmunol.0904057. Epub 2010 Mar 1.
5
'Unlicensed' natural killer cells dominate the response to cytomegalovirus infection.
Nat Immunol. 2010 Apr;11(4):321-7. doi: 10.1038/ni.1849. Epub 2010 Feb 28.
6
The activating receptor NKp46 is essential for the development of type 1 diabetes.
Nat Immunol. 2010 Feb;11(2):121-8. doi: 10.1038/ni.1834. Epub 2009 Dec 20.
7
Improved survival with inhibitory killer immunoglobulin receptor (KIR) gene mismatches and KIR haplotype B donors after nonmyeloablative, HLA-haploidentical bone marrow transplantation.
Biol Blood Marrow Transplant. 2010 Apr;16(4):533-42. doi: 10.1016/j.bbmt.2009.11.022. Epub 2009 Dec 2.
8
Natural killer cells: tolerance to self and innate immunity to viral infection and malignancy.
Biol Blood Marrow Transplant. 2010 Jan;16(1 Suppl):S97-S105. doi: 10.1016/j.bbmt.2009.10.009. Epub 2009 Oct 14.
9
How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets.
Immunity. 2009 Oct 16;31(4):654-64. doi: 10.1016/j.immuni.2009.08.023. Epub 2009 Oct 8.
10
Distinct conformations of Ly49 natural killer cell receptors mediate MHC class I recognition in trans and cis.
Immunity. 2009 Oct 16;31(4):598-608. doi: 10.1016/j.immuni.2009.07.007. Epub 2009 Oct 8.
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