采用连续流反应器通过原位生成的重氮盐的氯磺酰化反应制备芳基磺酰氯。
Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor.
机构信息
Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UKCB2 1EW.
出版信息
Org Biomol Chem. 2010 Dec 7;8(23):5324-32. doi: 10.1039/c0ob00450b. Epub 2010 Sep 27.
PMID:20877783
Abstract
A new flow procedure for the preparation of arylsulfonyl chlorides from aniline starting materials is described. The reaction conditions are mild, requiring no added acid and are amenable to continuous flow processing, in a safe, easily scalable and less labour intensive way than the corresponding batch method.
摘要
描述了一种从苯胺起始原料制备芳基磺酰氯的新的流动过程。反应条件温和，不需要添加酸，并且适用于连续流动处理，比相应的间歇方法更安全、更易于扩展且劳动强度更低。
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