人脑皮质-脑桥-小脑投射纤维束的弥散张量追踪：一项定量初步研究。
Diffusion tensor tractography of the human brain cortico-ponto-cerebellar pathways: a quantitative preliminary study.
机构信息
Department of Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
出版信息
J Magn Reson Imaging. 2010 Oct;32(4):809-17. doi: 10.1002/jmri.22330.
PURPOSE
To investigate the utility of diffusion tensor tractography at 1mm slice thickness to map and quantify the whole trajectory of different cortico-ponto-cerebellar pathways of the healthy adult human brain.
MATERIALS AND METHODS
This work was approved by the local Institutional Review Board, and was Health Insurance Portability and Accountability Act (HIPAA) compliant. Five healthy right-handed men (age range, 24-37 years) were studied and written informed consent was obtained. Diffusion tensor imaging data acquired with 1-mm slice thickness at a 3.0 Tesla (T) clinical MRI scanner were prepared and analyzed using tractography methods to reconstruct the cortico-ponto-cerebellar pathways which included the fronto-ponto-cerebellar, parieto-ponto-cerebellar, occipito-ponto-cerebellar, and temporo-ponto-cerebellar tracts.
RESULTS
We demonstrate the feasibility of tractographic mapping and quantification of the four cortico-ponto-cerebellar system components based on their cortical connections in the healthy human brain using DTI data with thin 1-mm sections.
CONCLUSION
In vivo quantification of different cortico-ponto-cerebellar pathways based on cortical connection is feasible, using 1-mm slices at 3.0T.
目的
研究在 1mm 层厚下弥散张量纤维束追踪技术在健康成人脑内不同皮质-脑桥-小脑通路的整体轨迹定位和定量的应用价值。
材料与方法
本研究获得了当地机构审查委员会的批准，并符合健康保险携带和责任法案（HIPAA）的规定。研究纳入了 5 名健康的右利手男性（年龄 24-37 岁），并获得了书面知情同意。在 3.0T 临床磁共振成像扫描仪上采集的 1mm 层厚弥散张量成像数据，使用纤维束追踪方法进行准备和分析，以重建包括额桥小脑束、顶桥小脑束、枕桥小脑束和颞桥小脑束在内的皮质-脑桥-小脑通路。
结果
我们展示了在健康人脑内，基于皮质连接，使用 1mm 薄层 DTI 数据，进行四种皮质-脑桥-小脑系统成分的纤维束追踪定位和定量的可行性。
结论
在 3.0T 场强下，使用 1mm 层厚，基于皮质连接的不同皮质-脑桥-小脑通路的活体定量是可行的。
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