血小板受体表达和功能的遗传调控：在临床实践和药物开发中的应用。
Genetic regulation of platelet receptor expression and function: application in clinical practice and drug development.
机构信息
Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Md 21224, USA.
出版信息
Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2372-84. doi: 10.1161/ATVBAHA.110.218131.
Abstract
Understanding genetic contributions to platelet function could have profound clinical ramifications for personalizing platelet-directed pharmacotherapy, by providing insight into the risks and possible benefits associated with specific genotypes. This article represents an integrated summary of presentations related to genetic regulation of platelet receptor expression and function given at the Fifth Annual Platelet Colloquium in January 2010. It is supplemented with additional highlights from the literature covering (1) approaches to determining and evidence for the associations of genetic variants with platelet hypo- and hyperresponsive phenotypes, (2) the ramifications of these polymorphisms with regard to clinical responses to antiplatelet therapies, and (3) the role of platelet function/genetic testing in guiding antiplatelet therapy.
摘要
了解遗传因素对血小板功能的影响，可能会对个体化的血小板靶向药物治疗产生深远的临床意义，因为它可以深入了解与特定基因型相关的风险和可能的益处。本文综合总结了 2010 年 1 月第五届血小板学术研讨会中有关血小板受体表达和功能遗传调控的演讲内容。此外，本文还补充了文献中的其他重点内容，涵盖了（1）确定遗传变异与血小板低反应和高反应表型关联的方法和证据，（2）这些多态性对抗血小板治疗临床反应的影响，以及（3）血小板功能/基因检测在指导抗血小板治疗中的作用。
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