病毒为何会致癌？人类肿瘤病毒学的首个百年亮点。
Why do viruses cause cancer? Highlights of the first century of human tumour virology.
机构信息
Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA.
出版信息
Nat Rev Cancer. 2010 Dec;10(12):878-89. doi: 10.1038/nrc2961. Epub 2010 Nov 24.
Abstract
The year 2011 marks the centenary of Francis Peyton Rous's landmark experiments on an avian cancer virus. Since then, seven human viruses have been found to cause 10-15% of human cancers worldwide. Viruses have been central to modern cancer research and provide profound insights into both infectious and non-infectious cancer causes. This diverse group of viruses reveals unexpected connections between innate immunity, immune sensors and tumour suppressor signalling that control both viral infection and cancer. This Timeline article describes common features of human tumour viruses and discusses how new technologies can be used to identify infectious causes of cancer.
摘要
2011 年是弗朗西斯·佩顿·劳斯（Francis Peyton Rous）进行禽类致癌病毒里程碑式实验的一百周年。自此，已发现七种人类病毒可导致全球 10%-15%的人类癌症。病毒一直是现代癌症研究的核心，为传染性和非传染性癌症病因提供了深刻的见解。这组多样化的病毒揭示了先天免疫、免疫传感器和肿瘤抑制信号之间出人意料的联系，这些联系既控制着病毒感染，又控制着癌症。这篇时间线文章描述了人类肿瘤病毒的共同特征，并讨论了如何利用新技术来确定癌症的感染性病因。
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