代谢和能量学的昼夜节律整合。
Circadian integration of metabolism and energetics.
机构信息
Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
出版信息
Science. 2010 Dec 3;330(6009):1349-54. doi: 10.1126/science.1195027.
Abstract
Circadian clocks align behavioral and biochemical processes with the day/night cycle. Nearly all vertebrate cells possess self-sustained clocks that couple endogenous rhythms with changes in cellular environment. Genetic disruption of clock genes in mice perturbs metabolic functions of specific tissues at distinct phases of the sleep/wake cycle. Circadian desynchrony, a characteristic of shift work and sleep disruption in humans, also leads to metabolic pathologies. Here, we review advances in understanding the interrelationship among circadian disruption, sleep deprivation, obesity, and diabetes and implications for rational therapeutics for these conditions.
摘要
生物钟使行为和生化过程与昼夜周期同步。几乎所有的脊椎动物细胞都拥有自我维持的生物钟，将内源性节律与细胞环境的变化联系起来。在小鼠中敲除生物钟基因会扰乱特定组织在睡眠/觉醒周期不同阶段的代谢功能。昼夜节律紊乱是人类轮班工作和睡眠障碍的一个特征，也会导致代谢性疾病。在这里，我们综述了对生物钟紊乱、睡眠剥夺、肥胖和糖尿病之间相互关系的理解进展，以及这些疾病合理治疗的意义。
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