循环脑源性神经营养因子水平：与情绪、认知和运动功能的相关性。

Circulating levels of brain-derived neurotrophic factor: correlation with mood, cognition and motor function.

机构信息

Laboratório de Imunofarmacologia, Departamento de Bioquímica & Imunologia, Instituto de Ciências Biológicas, UFMG Avenue Antonio Carlos, 6627 - 31270-901 - Belo Horizonte, MG, Brazil.

出版信息

Biomark Med. 2010 Dec;4(6):871-87. doi: 10.2217/bmm.10.111.

DOI:10.2217/bmm.10.111

PMID:21133708

Abstract

Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophin in the CNS, where it plays several pivotal roles in synaptic plasticity and neuronal survival. As a consequence, BDNF has become a key target in the physiopathology of several neurological and psychiatric diseases. Recent studies have consistently reported altered levels of BDNF in the circulation (i.e., serum or plasma) of patients with major depression, bipolar disorder, Alzheimer's disease, Huntington's disease and Parkinson's disease. Correlations between serum BDNF levels and affective, cognitive and motor symptoms have also been described. BDNF appears to be an unspecific biomarker of neuropsychiatric disorders characterized by neurodegenerative changes.

摘要

脑源性神经营养因子（BDNF）是中枢神经系统中分布最广泛的神经营养因子，在突触可塑性和神经元存活中发挥着多种关键作用。因此，BDNF 已成为几种神经和精神疾病生理病理学的关键靶点。最近的研究一致报告，在患有重度抑郁症、双相情感障碍、阿尔茨海默病、亨廷顿病和帕金森病的患者的循环（即血清或血浆）中，BDNF 水平发生改变。血清 BDNF 水平与情感、认知和运动症状之间的相关性也已被描述。BDNF 似乎是一种神经精神疾病的非特异性生物标志物，其特征是神经退行性变化。