新型3-(4-氨基)苯基亚氨基)-5-氟吲哚啉-2-酮席夫碱类似物的合成与药理评价
Synthesis and Pharmacological Evaluation of Novel Schiff Base Analogues of 3-(4-amino) Phenylimino) 5-fluoroindolin-2-one.
作者信息
Nirmal R, Prakash Cr, Meenakshi K, Shanmugapandiyan P
机构信息
Department of Pharmaceutical Chemistry, Balaji Institute of Pharmacy, Laknepally (V), Narsampet (M), Warangal, Andhra Pradesh - 506 331, India.
出版信息
J Young Pharm. 2010 Apr;2(2):162-8. doi: 10.4103/0975-1483.63162.
Abstract
In our study, a series of novel 3-(4-(benzylideneamino) phenylimino) 4-fluoroindolin-2-one derivatives were synthesized and characterized by spectral (I.R, (1)H NMR, mass) and elemental analysis. The title compounds (N(1)-N(10)) were evaluated for analgesic, anti-inflammatory, and ulcerogenic index activities. Results displayed that compound N(3) exhibited significant analgesic activity. Among the title compounds studied, N(2), N(3), and N(8) exhibited significant anti- inflammatory activity comparable to reference standard diclofenac sodium. Interestingly, the test compounds showed only mild ulcerogenic side effect when compared to aspirin.
摘要
在我们的研究中，合成了一系列新型的3-(4-(亚苄基氨基)苯基亚氨基)-4-氟吲哚啉-2-酮衍生物，并通过光谱（红外光谱、¹H核磁共振谱、质谱）和元素分析对其进行了表征。对标题化合物（N(1)-N(10)）进行了镇痛、抗炎和致溃疡指数活性评估。结果显示化合物N(3)表现出显著的镇痛活性。在所研究的标题化合物中，N(2)、N(3)和N(8)表现出与参考标准双氯芬酸钠相当的显著抗炎活性。有趣的是，与阿司匹林相比，测试化合物仅表现出轻微的致溃疡副作用。
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