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犬肉瘤相关病理性骨折修复后的预后:外科肿瘤学兽医协会回顾性研究

Outcome after repair of a sarcoma-related pathologic fracture in dogs: a Veterinary Society of Surgical Oncology Retrospective Study.

作者信息

Boston Sarah E, Bacon Nicholas J, Culp William T N, Bhandal Jitender, Bruce Charles, Cavanaugh Ryan P, Hamilton Michael H, Lincoln James D, Liptak Julius M, Scharvogel Stefan

机构信息

Department of Clinical Studies, University of Guelph, Guelph, ON, Canada.

出版信息

Vet Surg. 2011 Jun;40(4):431-7. doi: 10.1111/j.1532-950X.2011.00820.x. Epub 2011 Mar 21.

Abstract

OBJECTIVE

To report outcome in dogs after internal fixation of a sarcoma-related pathologic fracture of the appendicular skeleton.

STUDY DESIGN

Multi-institutional case series.

ANIMALS

Dogs (n=16).

METHODS

Medical records of participating VSSO members were reviewed for dogs with pathologic fracture associated with a confirmed bone sarcoma of the appendicular skeleton repaired by external or internal fixation. Dogs were included if they had a histological diagnosis of osteosarcoma or sarcoma and excluded if they had radiation before fracture. Data collected were analyzed for signalment, fracture location, staging performed, method of fracture fixation, histopathology, adjunctive treatment and outcome.

RESULTS

Signalment and fracture location of 16 dogs that met the inclusion criteria was similar to dogs with appendicular OSA without fracture. One of 14 dogs had pulmonary metastasis and 3 of 5 dogs had bone metastasis. Bone plate or interlocking nail were used for repair in 12 dogs. Limb use immediately after surgery in 13 dogs was good (4), weight-bearing but lame (7) and non-weight bearing (2). Adjunctive therapy was administered in 5 dogs (chemotherapy, 3; radiation, 4; pamidronate, 3). Survival time ranged from 18 to 897 days; median survival was 166 days.

CONCLUSIONS

Repair of pathologic fracture can result in palliation and prolonged survival.

摘要

目的

报告犬四肢骨骼肉瘤相关病理性骨折内固定术后的结果。

研究设计

多机构病例系列。

动物

犬(n = 16)。

方法

回顾参与的兽医外科肿瘤学会(VSSO)成员的医疗记录,查找因确诊的四肢骨骼骨肉瘤而导致病理性骨折并采用外固定或内固定修复的犬。若犬组织学诊断为骨肉瘤或肉瘤则纳入研究,若在骨折前接受过放疗则排除。对收集的数据进行分析,内容包括品种、年龄、性别、骨折部位、分期、骨折固定方法、组织病理学、辅助治疗及结果。

结果

符合纳入标准的16只犬的品种、年龄、性别和骨折部位与未发生骨折的四肢骨肉瘤犬相似。14只犬中有1只发生肺转移,5只犬中有3只发生骨转移。12只犬采用接骨板或交锁髓内钉进行修复。13只犬术后肢体使用情况良好(4只)、可负重但跛行(7只)和不可负重(2只)。5只犬接受了辅助治疗(化疗3只;放疗4只;帕米膦酸盐3只)。生存时间为18至897天;中位生存时间为166天。

结论

病理性骨折的修复可缓解症状并延长生存期。

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